Lihlahisoa

Trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid ke motsoako oa lik'hemik'hale o nang le lisebelisoa tse fapaneng tse ka sebelisoang lefapheng la organic synthesis le lipatlisiso tsa meriana.E khetholloa ka ho ba teng ha selikalikoe sa pyrrolidine se nkeloang sebaka ke sehlopha se sireletsang sa tert-butoxycarbonyl (Boc) ho athomo ea nitrogen le sehlopha sa trifluoromethyl holim'a lesale la phenyl. E 'ngoe ea lisebelisoa tsa bohlokoa tsa trans-1-(tert-Butoxycarbonyl) - 4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid e le karolo e bohareng ea motsoako oa metsoako e meng ea tlhaho.Sebopeho sa eona se ikhethang le lihlopha tse sebetsang li etsa hore e be mohaho o rarahaneng oa ho haha ​​​​limolek'hule tse rarahaneng.Sehlopha sa Boc se sebetsa e le sehlopha se sireletsang, se ka tlosoang ka mokhoa o ikhethileng tlas'a maemo a itseng a karabelo ho pepesa sebaka sa ts'ebetso bakeng sa liphetoho tse ling.Sena se lumella liphetoho tse laoloang le tse nepahetseng tsa manyolo.Sehlopha sa trifluoromethyl se trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid se boetse se fana ka thepa ea bohlokoa le mekhoa e ka sebelisoang.Lihlopha tsa Trifluoromethyl li tsejoa ka tlhaho ea tsona ea ho hula elektronike le lipophilicity, tse ka ntlafatsang matla, botsitso ba metabolism, le bioavailability ea batho ba sebelisang lithethefatsi.Ho phaella moo, sehlopha sa trifluoromethyl se ka fetola thepa ea physicochemical ea motsoako, e amang solubility, lipophilicity, le receptor e tlamang kamano. carboxylic acid e ka bonts'a ts'ebetso ea tlhaho ka boeona kapa joalo ka sehlahisoa.Lihlahisoa ke metsoako e sa sebetseng ea biologically e fetohang lik'hemik'hale kapa tsa enzymatic 'meleng ho fetoha lithethefatsi tse sebetsang.Maemong a mang, sehlopha sa tšireletso sa Boc se ka 'na sa tlosoa ka mokhoa o ikhethileng ka har'a vivo, ho etsa hore motsoako o be le phello e lakatsehang ea phekolo.Le hoja likopo tse khethehileng le tšebeliso e ka sebelisoang bakeng sa trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl) phenyl)pyrrolidine-3-carboxylic acid li ngata, lipatlisiso tse ling le lipatlisiso lia hlokahala ho hlahloba bokhoni ba eona bo felletseng.Hangata sena se kenyelletsa ntlafatso ea k'hemistri ea bongaka, lithuto tsa likamano tsa sebopeho le ts'ebetso, le tlhahlobo ea baeloji.Ka ho utloisisa ka botlalo thepa ea motsoako le ts'ebetso ea ts'ebetso, bo-ramahlale ba ka lekola ho tšoaneleha ha eona bakeng sa ho shebana le mafu kapa maemo a itseng, e leng se lebisang ho nts'etsopele ea batho ba batlang ho sebelisa lithethefatsi kapa li-catalytic agents nakong e tlang.