Tiamulin 98% Cas: 125-65-5
| Nomoro ea lethathamo | XD91893 |
| Lebitso la Sehlahiswa | Tiamulin 98% |
| CAS | 125-65-5 |
| Foromo ea molek'hulela | C22H34O5 |
| Boima ba Molek'hule | 378.5 |
| Lintlha tsa polokelo | -20°C |
| Khoutu ea Lekhetho e Kopantsoeng | 2918199090 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu |
| Assay | 99% mets |
| Sebaka se qhibilihang | 170-1710C |
| alpha | D24 +20° (c = 3 ho abs ethanol) |
| Ntho e belang | 482.8±45.0 °C(E boletsoeng esale pele) |
| tekano | 1.15±0.1 g/cm3(E boletsoeng esale pele) |
| ho qhibiliha | DMSO:> 10mg/mL (e futhumala) |
| pka | 12.91±0.10(E boletsoeng esale pele) |
| tshebetso ya mahlo | [α]/D +30 ho +40° (c=1; CH2Cl2) |
Pleuromutilin ke diterpene e hlahisoang ke mefuta e mengata ea basidomycete, haholo-holo mofuta oa Pleurotus, o fumanoeng ka 1951. Pleuromutilin ke lithibela-mafu tse matla le tse khethang haholo tse sebetsang khahlanong le mefuta e mengata ea libaktheria tsa Gram positive, tse se nang khanyetso ho lihlopha tse teng tsa lithibela-mafu ka lebaka la mokhoa oa eona o ikhethang. ea ketso.Pleuromutilin e thibela protheine synthesis ka ho tlama ho domain V ea 23S rRNA mme sena se lebisitse ho nts'etsopele ea li-analogue tse ngata tsa semi-synthetic joalo ka lithibela-mafu tsa moloko o mocha, joalo ka tiamulin le retapamulin.
Pleuromutilins tse kang tiamulin le valnemulin li 'nile tsa sebelisoa ka nako e itseng meriana ea bongaka ba liphoofolo ho phekola mafu a likolobe.Haufinyane tjena ho hlahisitsoe semisynthetic pleuromutilin, retapamulin, e le pheko e ka sehloohong bakeng sa tšoaetso ea Gram-positive bathong.Pleuromutilins e thibela tšebetso ea peptidyl transferase ea baktheria 50S ribosomal subunit ka ho tlama sebakeng sa A.
