Telithromycin Cas: 191114-48-4
Nomoro ea lethathamo | XD92372 |
Lebitso la Sehlahiswa | Telithromycin |
CAS | 191114-48-4 |
Foromo ea molek'hulela | C43H65N5O10 |
Boima ba Molek'hule | 812.00 |
Lintlha tsa polokelo | 2 ho isa ho 8 °C |
Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
Ponahalo | Phofo e tšoeu ho isa ho e tšoeu ea kristale |
Assay | 99% mets |
Metsi | 1.0% boholo |
Litšepe tse boima | 20ppm max |
Masalla a ho Ignition | 0.2% boholo |
Telithromycin e ile ea qalisoa ka lekhetlo la pele Jeremane e le phekolo ea molomo hanngoe ka letsatsi bakeng sa mafu a ho hema ho akarelletsa le pneumonia e fumanoang ke sechaba, ho mpefala ha baktheria ea bronchitis e sa foleng, sinusitis e matla le tonsillitis/pharyngitis.Motsoako ona oa semisynthetic oa macrolide erythromycin ea tlhaho ke ketolide ea pele e rekisoang, sehlopha se secha sa lithibela-mafu se nang le C3-ketone sebakeng sa sehlopha sa L-cladinose.Sehlahisoa sa antibacterial sa litho tse 14 se thibela motsoako oa protheine ea baktheria ka ho tlama likarolo tse peli tsa karoloana ea 50S ea li-ribosome tsa baktheria.E bonts'a ts'ebetso e matla ea in vitro khahlano le likokoana-hloko tse tloaelehileng tsa phefumoloho ho kenyelletsa Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis le Streptococcus pyogenes hammoho le likokoana-hloko tse ling tse sa tloaelehang.Sehlopha sa 3-keto se fana ka botsitso bo eketsehileng ba acidic le ho fokotsa ho kenngoa ha macrolide-lincosamide-streptogramin B ho hanyetsa e bonoang khafetsa ka macrolides.Sebaka sa C11-C12 carbamate residue ha se bonahale feela ho eketsa kamano bakeng sa sebaka se tlamang sa ribosomal empa hape le ho tsitsisa motsoako khahlanong le esterase hydrolysis le ho qoba ho hanyetsa ka lebaka la ho felisoa ha macrolides seleng ka pompo ea efflux e kentsoeng ke mef gene ho likokoana-hloko tse itseng. .Telithromycin ka bobeli ke inhibitor ea competitive le substrate ea CYP3A4.Leha ho le joalo, ho fapana le li-macrolide tse 'maloa tse kang troleandomycin, ha e thehe mokhoa o tsitsitseng oa inhibitory CYP P-450 Fe2 + -nitrosoalkane metabolite complex e ka 'nang ea e-ba hepatotoxic.Setlhare se mamelloa hantle 'me se ajoa hantle ka har'a lisele tsa pulmonary, li-secretions tsa bronchial, lithane le mathe.E bonahala e tsepamisitsoe haholo ka har'a li-azurophil granules tsa polymorphonuclear neutrophils ka tsela eo e nolofaletsa ho tlisoa ha eona ho libaktheria tsa phagocytosed.