Lihlahisoa

Flow cytometry ke mokhoa oa sepheo sa ho etsa liteko tsa in vitro antimalarial sensitivity ka menyetla e ntseng e eketseha ea ts'ebeliso libakeng tsa masimo.Re ile ra hlahloba in vitro susceptibility ho lithethefatsi tse supileng tse khahlanong le malarial bakeng sa 40 fresh P. falciparum field isolates ka mokhoa oa flow cytometry (FCM), colorimetric LDH-based ELISA: DELI), le tlhahlobo e tloaelehileng ea microscopic slide ea ho hōla.Bakeng sa FCM, litlhahlobo tsa 184/280 (66%) li fihletse litekanyetso tsa ho amoheloa ha tlhahlobo, ha li bapisoa le 166/280 (59%) bakeng sa DELI.Ho ne ho e-na le tumellano e ntle pakeng tsa FCM le microscopy, athe DELI e ne e atisa ho hlahisa li-inhibition constants (IC50s) tse phahameng ho feta FCM, ka kakaretso ea 2.2-fold (papiso ea Bland-Altman).Maemo a artesunate le dihydroartemisinin a amehile haholo.Keketseho e makatsang ea lets'oao maemong a phahameng haholo a mefloquine le metsoako e amanang le eona e ne e tšoailoe haholoanyane ka tlhahlobo ea DELI, e fana ka maikutlo a hore litlamorao tse sa lebelloang tlhahisong ea LDH li ka ikarabella.Tahlehelo ea lets'oao la FCM ka lebaka la ho khutlisoa kapa ho hola butle ho ile ha bonoa ka palo e nyane ea disampole.Liphetho tsena li eketsa mosebetsi oa nakong e fetileng mabapi le tšebeliso ea phallo ea cytometry ho fumana ts'oaetso ea antimalarial ho latela palo ea lisampole, mefuta e mengata ea lithethefatsi, le ho bapisoa le mekhoa e meng.