Spiramycin Cas: 8025-81-8
| Nomoro ea lethathamo | XD90452 |
| Lebitso la Sehlahiswa | Spiramycin |
| CAS | 8025-81-8 |
| Foromo ea limolek'hule | Setšoantšo sa C43H74N2O14 |
| Boima ba Molek'hule | 843.05 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e Tshweu |
| Tlhahlobo | > 4100IU/mg |
| Litšepe tse boima | <20ppm |
| Tahlehelo ka ho Omisa | <3.5% |
| Molora oa Sulfate | <1.0% |
| Ethanol | <2.0% |
| Potoloho e khethehileng ea optical | -85 ho ea ho -80 likhato |
Streptomyces ambofaciens e kopanya lithibela-mafu tsa macrolide spiramycin.Sehlopha sa liphatsa tsa lefutso tsa biosynthetic bakeng sa spiramycin se khetholloa bakeng sa S. ambofaciens.Ho phaella ho liphatsa tsa lefutso tsa srmR (srm22), tse neng li tsejoa pele (M. Geistlich et al., Mol. Microbiol. 6: 2019-2029, 1992), liphatsa tsa lefutso tse tharo tsa taolo li ne li khethiloe ka tlhahlobo ea tatellano.Tlhahlobo ea polelo ea liphatsa tsa lefutso le liteko tsa ho se sebetse ha liphatsa tsa lefutso li bontšitse hore ke e le 'ngoe feela ea liphatsa tsa lefutso tsena tse tharo, srm40, e nang le karolo e kholo taolong ea spiramycin biosynthesis.Tšitiso ea srm22 kapa srm40 e felisitse tlhahiso ea spiramycin ha maikutlo a bona a feteletseng a eketsa tlhahiso ea spiramycin.Tlhaloso ea polelo e entsoe ke reverse transcription-PCR (RT-PCR) bakeng sa liphatsa tsa lefutso tsa sehlopha sa mofuta o hlaha le ho srm22 (srmR) le srm40 deletion mutants.Liphetho tsa tlhahlobo ea polelo, hammoho le tse tsoang litekong tsa tlatsetso, li bonts'itse hore Srm22 ea hlokahala bakeng sa polelo ea srm40, Srm40 e le sets'oants'o se ikhethileng sa tsela se laolang boholo, haeba e se kaofela, ba liphatsa tsa lefutso tsa spiramycin biosynthetic.
