Lihlahisoa

Ho batlisisa ka epidemiology ea molek'hule ea li-isolates tsa Neisseria gonorrhoeae ho tloha Saskatchewan, Canada, ho sebelisa Neisseria gonorrhoeae multi antigen sequence typing (NG-MAST), le ho hlahloba likamano pakeng tsa tšoaetso ea antimicrobial (AMS) le mefuta e itseng ea khatello (STs). , tse bokelletsoeng pakeng tsa 2003 le 2008, li ngotsoe ke NG-MAST.Li-ST li ne li arotsoe haeba e 'ngoe ea li-alleles tsa tsona e ne e tloaelehile' me e 'ngoe e fapane ka ≤1% ka tatellano ea DNA.AMS e ile ea khethoa ke agar dilution (CLSI) ho lithibela-mafu tse supileng. Li-isolates tsa N gonorrhoeae li ile tsa rarolloa ka lihlopha tse 82 tsa batho ba NG-MAST le lihlopha tse 18 tsa NG-MAST ST tse nang le lihlopha tsa 25, 3655, 921, 3654, 3657 le 3656 tse nang le 53.4% ​​(13.4%). /320) ea libaka tse ka thoko.N gonorrhoeae isolates tse hlaselehang habonolo ho li-antimicrobial tse lekiloeng li ne li le teng haholo (p<0.05) tse amanang le ST 25 (87%).Likamano tse ling tsa bohlokoa pakeng tsa ST le AMS li kenyelelitsoe: ST 3654 le ho itšehla thajana ka bonyane ba inhibitory concentrations ea ≥0.03 mg / L ho isa molokong oa boraro oa ceph alosporins;ST 3711 (100%) le TRNG;le ST / sehlopha sa 3654 (43%) le ho hanyetsa chromosomal ho penicillin le tetracycline.Lihlopha tse 'maloa tsa NG-MAST / lihlopha li ne li amahanngoa haholo le li-isolate tse nang le chromosomal ho hanyetsa tetracycline.Li-isolates tse hanyetsanang le ciprofloxacin (n=5) le azithromycin (n=2) li hlahile e le STS ka bomong.Likamano tsa bohlokoa li ile tsa hlokomeloa har'a STs ka bomong, thobalano le lilemo tsa mokuli, le kabo ea libaka le ea nakoana. Likamano pakeng tsa N gonorrhoeae AMS le NG-MAST STs li ile tsa khetholloa 'me li ka ba molemo ho bolela esale pele AMS sebakeng sa heno.Hobane li-ST linaheng tse fapaneng li fapana haholo, tšebeliso ea NG-MAST bakeng sa ho bolela esale pele ka AMS lefatšeng ka bophara e hloka boithuto bo eketsehileng.