Lihlahisoa

Lik'hemik'hale tse ngata li ntse li phehelloa ka ho eketsehileng bakeng sa phekolo e sebetsang ea mafu a rarahaneng.Mona, re hlalosa moralo le sebopeho sa sehlopha sa li-shogaol-huprine hybrids, tseo ho thoeng li otla liphofu tse 'maloa tse amehang lefung la Alzheimer's.Li-hybrids li 'nile tsa lekoa ka in vitro bakeng sa ts'ebetso ea tsona ea ho thibela batho ho thibela acetylcholinesterase le butyrylcholinesterase le antioxidant mosebetsi (ABTS +, DPPH le Folin-Ciocalteu assays), le lisele tsa Escherichia coli tse tsitsitseng bakeng sa mosebetsi oa bona oa Aβ42 le tau anti-aggregating.Hape, ho kenella ha boko ba bona ho hlahlojoe (PAMPA-BBB assay).Le hoja li-hybrids li se matla a AChE inhibitors kapa li-antioxidant joalo ka motsoali oa huprine Y le [4] -shogaol, ka ho latellana, li ntse li bontša liketso tse matla haholo tsa anticholinesterase le antioxidant 'me li matla haholo Aβ42 le li-anti-aggregating agents ho feta metsoako ea motsoali.Ka kakaretso, mefuta e nyalisitsoeng ea shogaol-huprine e hlaha e le boko bo khahlang bo nang le litebello tse ngata tsa anti-Alzheimer.

Lits'oants'o tsa polarity tse fapaneng tse fumanoeng likarolong tse fapaneng tsa limela (motso, lekhasi, palesa le litholoana) tsa Seseli rigidum li ile tsa ithutoa ka litlhahlobo tse fapaneng tsa li-antioxidant: ts'ebetso ea DPPH le ABTS ea scavenging, ka mokhoa o felletseng oa ho fokotsa matla hammoho le litaba tsa flavonoids le polyphenols. .Oli ea bohlokoa ea likarolo tsohle tsa semela e bontšitse litšobotsi tse fokolang tsa antioxidant.The inhibitory concentration range of tests extracts, against the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, le fungus Candida albicans le Aspergillus niger e ne e le 0.01-1.50 mg/mL le ea microbicidal 30 mg/mL 0.0 mg 0.0.Tšebelisanong le cholinesterase, oli eohle ea bohlokoa e ipakile e sebetsa e le li-inhibitors.Liphesente tse phahameng ka ho fetisisa tsa thibelo khahlanong le batho le lipere tsa cholinesterase li bontšitsoe ka motso oa oli ea bohlokoa (38.20% le 48.30%, ka ho latellana) har'a oli, le motso oa hexane extract (40.56% le 50.65% ka ho latellana).Lioli tsa bohlokoa le likarolo tse sa fetoheng tsa likarolo tsohle tsa semela li ile tsa khetholloa ke GC, GC-MS le headspace/GC-MS.Tlhahlobo ea lipalo-palo ea sephetho sa liphetho e bonts'itse hore motsoako oa oli ea bohlokoa o fapane haholo le oli ea bohlokoa ea likarolo tse ling tsa semela.Ha ho nahanoa ka mesebetsi eohle e ithutoang, motso oa hexane o bonts'a thepa e ntle ka ho fetesisa.Ka tšebeliso e phahameng ea chromatography ea mokelikeli e kopantsoeng le spectrometry ea boima bo phahameng, likarolo tse 30 tse ngata haholo li ile tsa khetholloa liqosong tse fapaneng tsa polarity.Boteng ba likarolo tse khethiloeng bo ne bo amahanngoa le mesebetsi e khethehileng ea likokoana-hloko, kahoo ho hlahisa metsoako e ka 'nang ea ikarabella bakeng sa ketsahalo e' ngoe le e 'ngoe e bontšitsoeng.