(S)-2-Amino-4-hydroxybutanoic acid Cas: 672-15-1
| Nomoro ea lethathamo | XD90286 |
| Lebitso la Sehlahiswa | (S) -2-Amino-4-hydroxybutanoic acid |
| CAS | 672-15-1 |
| Foromo ea limolek'hule | C4H9NO3 |
| Boima ba Molek'hule | 119.11916 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29225000 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
Boithuto ba hajoale bo hlalosa mokhoa o bonolo le o sebetsang o sebelisang chromatography ea metsi a phahameng a sebetsang (HPLC) hammoho le ho lemoha ha fluorescence bakeng sa ho fumana lintlha tsa kinetic tsa ts'ebetso ea glutamate liseleng tsa methapo.Li-tissue tsa retina tse fumanoeng ho litsuonyana tsa matsatsi a 7 li ne li kenngoa ka metsoako e tsejoang ea glutamate (50-2000 μM) bakeng sa metsotso e 10, 'me maemo a o-phtaldehyde (OPA) -derivatized neurotransmitter ka mokhoa oa ho incubation a ile a lekanngoa.Ka ho hlahloba phapang pakeng tsa likhahla tsa pele le tsa ho qetela tsa glutamate bohareng, mokhoa o tsitsitseng oa ho kenngoa o ne o khetholloa (K (m) = 8.2 le V (max) = 9.8 nmol / mg protheine / min).Tekanyo ena e ne e itšetlehile haholo ka sodium le mocheso, e tšehetsa ka matla hore mochine oa ho fokotseha ha mahloriso o nkoa ke lipalangoang tse phahameng haholo.Ho phaella ho sena, liphetho tsa rona li boetse li bonts'a hore zinc chloride (inhibitor ea glutamate / aspartate transporters) e hlahisitse ho fokotseha ho itšetlehileng ka mahloriso ho glutama te uptake, ho bontša ho khetheha ha mokhoa oa rona.Ka kakaretso, mosebetsi oa hajoale o bontša mokhoa o mong oa ho lekola ts'ebetso ea glutamate liseleng tsa methapo e sebelisang HPLC.Mokhoa ona e ka ba sesebelisoa sa bohlokoa bakeng sa liphuputso tse amanang le sebopeho sa liphetoho tsa metsotsoana ho lipalangoang tsa glutamate tse amanang le kotsi ea tsamaiso ea methapo ea bohareng.
