Tharollo ea Poly-L-lysine ( 0.1%) Cas: 25988-63-0
| Nomoro ea lethathamo | XD90306 |
| Lebitso la Sehlahiswa | Tharollo ea Poly-L-lysine ( 0.1%) |
| CAS | 25988-63-0 |
| Foromo ea limolek'hule | C18H38N6O4 |
| Boima ba Molek'hule | 402.532124042511 |
| Lintlha tsa polokelo | 2-8°C |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 0.1% |
| Ponahalo | Seela se se nang mmala |
Liphetoho tsa eucine-rich repeat kinase 2 (LRRK2) ke sesosa se tsebahalang haholo sa lefu la Parkinson (PD).Likarolo tsa kliniki tsa LRRK2 PD ha li khethollehe ho idiopathic PD, ka ho bokellana ha α-synuclein le/kapa tau le/kapa ubiquitin ka li-aggregates tsa intraneuronal.Sena se fana ka maikutlo a hore LRRK2 ke senotlolo sa ho utloisisa hore na lefu lena le bakoa ke eng.Le hoja ho lahleheloa ke mosebetsi ho sa bonahale e le mokhoa o bakang PD ho bakuli ba LRRK2, ha ho hlake hore na protheine ena e kopanya chefo joang.Phuputsong ena, re tlaleha hore LRRK2 overexpression ka liseleng le ka vivo e senya mosebetsi oa tsela ea ubiquitin-proteasome, le hore sena se ikarabella bakeng sa ho bokella li-substrates tse sa tšoaneng tse nang le LRRK2 overexpression.Re bonts'a hore sena ha se kopane le LRRK2 aggregates kapa sequestration ea ubiquitin ho aggregates.Habohlokoa, lintho tse joalo tse sa tloaelehang ha li bonoe ka ho feteletsa ha protheine e amanang le LRRK1.Lintlha tsa rona li fana ka maikutlo a hore LRRK2 e thibela ho tlosoa ha proteasome substrate s holimo ho ts'ebetso ea proteasome catalytic, e ratang ho bokella liprotheine le ho thehoa ha lihlopha.Kahoo, re fana ka kamano ea limolek'hule pakeng tsa LRRK2, sesosa se tsebahalang ka ho fetisisa sa PD, le phenotype e hlalositsoeng pele ea ho bokella protheine.
