Platinum ho activated carbon Cas:7440-06-4
| Nomoro ea lethathamo | XD90696 |
| Lebitso la Sehlahiswa | Platinum ho activated carbon |
| CAS | 7440-06-4 |
| Foromo ea limolek'hule | Pt |
| Boima ba Molek'hule | 195.08 |
| Lintlha tsa polokelo | 2-8°C |
| Khoutu ea Lekhetho e Kopantsoeng | 28439000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | silvery-gray meta |
| Tlhahlobo | 99% |
| Density | 21.45 |
| Sebaka se qhibilihang | 1772 ℃ |
| Ntho e belang | 3827 ℃ |
| Refractive Index | n20/D 1.347 |
| flash point | 3825°C |
| Khatello ea mouoane | 0 mm Hg (hoo e ka bang) (NIOSH, 2016) |
Ho hlahloba li-anticancer tse thehiloeng ho platinum tse fapaneng le sebopeho le tšebelisano ea cisplatin ea setso ka ho theha "bifunctional intrastrand 1,2 GpG adduct", "monofunctional platinum + DNA adducts" e nang le litšebelisano tse ngata tse se nang likamano li ithutile.Ho ile ha tlalehoa hore mahlahana a monofunctional testosterone-based platinum(II) a hlahisa tšebetso e phahameng ea anticancer.Ho feta moo, ho ile ha boela ha fumanoa hore li-agent tsa platinamo tse thehiloeng ho testosterone li ka etsa hore DNA helix e be le ho phutholoha le ho inamela holim'a lisebelisoa tsa platinum tse se nang testosterone.Leha ho le joalo, mekhoa ea ho sebelisana ea li-agent tsena tsa platinum tse nang le DNA boemong ba athomo ha li e-s'o hlake ho fihlela joale. e thehiloeng platinum + DNA, platinum + DNA e ntlafalitsoeng ea testosterone le li-adducts tse se nang testosterone-based platinum + DNA.Liphetho li bonts'a hore tšebelisano-'moho ea platinamo e ntlafalitsoeng ea testosterone-based agent e nang le molek'hule ea DNA e ka baka khopamiso e kholo ea DNA ho feta tšebelisano ea sefahleho sa "testosterone-based platinum agent" e nang le molek'hule ea DNA.Liphuputso tse ling bakeng sa moemeli oa platinum e seng testosterone-based li senola ho hlaha ha phetoho e nyenyane ea DNA conformation ka lebaka la ho ba sieo ha testosterone ligand ho moemeli ea joalo.Ho ipapisitsoe le tlhahlobo ea matla a DNA, metsamao ea motheo ea DNA e amanang le liphetoho tsa parameter ea DNA groove le timetso ea hydrogen bond ea DNA base pairs le tsona li ile tsa buisanoa mosebetsing ona.The flexible linker in the testosterone-based based platinum agent e baka tšebelisano-'moho le DNA. e ntlafalitsoeng ea testosterone-based platinum + DNA adduct, e fapaneng le tšebelisano ea sefahleho sa groove e bakoang ke sehokelo se thata ho testosterone-based platinum agent.Liphuputso tse teng hona joale li fana ka tlhahisoleseding e molemo ea DNA conformation angoa ke testosterone-based platinum complex boemong ba athomo.
