p-hydoxybenzoic acid,monosodium Cas:114-63-6 99% E tšoeu ho isa ho phofshoana e mosehla kapa e bosoeu ea kristale
Nomoro ea lethathamo | XD90141 |
Lebitso la Sehlahiswa | P-hydoxybenzoic acid, monosodium |
CAS | 114-63-6 |
Foromo ea limolek'hule | C7H5O3Na |
Boima ba Molek'hule | 160.10 |
Lintlha tsa polokelo | Ambient |
Khoutu ea Lekhetho e Kopantsoeng | 2918290000 |
Tlhaloso ea Sehlahisoa
Ponahalo | Bosoeu ho isa ho phofshoana e mosehla kapa e bosoeu bo bosoeu ba kristale |
Assay | ≥ 99% |
Botenya | 1.3750 |
Sebaka se qhibilihang | >300 °C(hote.) |
Ntho e belang | 336.2°Cat760mmHg |
flash point | 171.3°C |
Thibelo ea β-carbonic anhydrases (CAs, EC 4.2.1.1) ho tsoa ho fungus ea pathogenic Cryptococcus neoformans (Can2) le Candida albicans (Nce103) e nang le letoto la 25 branched aliphatic le carboxylate e nkhang hamonate e 'nile ea batlisisoa.Li-isoforms tsa batho hCA I le II le tsona li kenyelelitsoe thutong bakeng sa ho bapisa.Aliphatic carboxylates ka kakaretso e ne e le milimilar hCA I le II inhibitors le li-inhibitors tse tlase tsa micromolar/submicromolar β-CA.Li-carboxylate tse nkhang hamonate e ne e le li-micromolar inhibitors tsa li-enzyme tse 'nè empa tse ling tsa tsona li ne li bontša ts'ebetso e tlase ea nanomolar khahlano le li-enzyme tsa fungal pathogenic.4-Hydroxy- le 4-methoxy-benzoate e thibetsoe Can2 ka K(I)s ea 9.5-9.9 nM.Li-methyl esters, hydroxamates, hydrazides le carboxamides tsa tse ling tsa li-derivatives tsena le tsona e ne e le li-inhibitors tse sebetsang tsa α- le β-CAs li ile tsa fuputsoa mona.
Li-parabens ke tse ling tsa li-preservative tse sebelisoang khafetsa ho thibela kholo ea likokoana-hloko le ho lelefatsa bophelo ba sethala sa mefuta e mengata ea lihlahisoa tsa bareki.Sepheo sa thuto ea hona joale e ne e le ho fumana temohisiso mabapi le metabolism ea parabens liseleng tsa mofetše oa matsoele (MCF7) kaha li bontšitse ts'ebetso ea estrogenic ho lisele tsena 'me li fumanoe liseleng tsa kankere ea matsoele.Chefo ea li-parabens ho lisele tsa MCF7 e ile ea khethoa ho sebelisoa liteko tsa MTT.Hydrolysis ea methyl-, butyl le benzyl-paraben ho p-hydroxybenzoic acid e ile ea hlahlobjoa liseleng tsa MCF7 tse hlahisitsoeng le ho li-homogenate tsa cellular.Glucuronidation le sulfoconjugation li ile tsa ithutoa ho li-homogenates tsa MCF7, 'me li-parabens li ile tsa hlahlojoa ke HPLC.Methyl-paraben e bontšitsoe e le chefo e nyane haholo ho feta butyl le benzyl-paraben.Li-Parabens li ne li tsitsitse ka ho feletseng ho li-homogenates tsa MCF7 athe p-nitrophenyl acetate, mofuta oa substrate, o ile oa etsoa hydrolysis.Li-homogenates tsa lisele tsa MCF7 ha lia ka tsa hlahisa mesebetsi ea glucuronidation le sulfoconjugation ho li-parabens.Ho ba le botsitso bo phahameng ba parabens ho ka hlalosa ho bokellana ha bona meleng ea mofetše oa matsoele.