Lihlahisoa

Linagliptin Intermediate F, eo hape e tsejoang e le 3-aminopiperidine-1-carboxylic acid, ke motsoako oa bohlokoa oa lik'hemik'hale ha ho etsoa linagliptin, moriana o sebelisetsoang ho phekola lefu la tsoekere la mofuta oa 2.Linagliptin ke ea sehlopha sa meriana e bitsoang dipeptidyl peptidase-4 inhibitors (DPP-4) inhibitors, e thusang ho laola maemo a tsoekere ea mali.E sebetsa e le moaho oa bohlokoa ho theha sebopeho se ikhethileng sa lik'hemik'hale tsa linagliptin ka ho etsa letoto la karabelo.Sena se bohareng se sebelisoa ka ho khetheha ha ho qaptjoa lesale la mantlha la piperidine ea sebopeho sa limolek'hule tsa linagliptin. Hang ha linagliptin e se e entsoe, e sebetsa ka ho thibela tšebetso ea enzymatic ea DPP-4.Li-inhibitors tsa DPP-4 li sebetsa ka ho thibela ho senyeha ha lihomone tsa incretin, tse kang glucagon-like peptide-1 (GLP-1), tse ikarabellang bakeng sa ho susumetsa ho lokolloa ha insulin le ho hatella secretion ea glucagon.Ka ho thibela DPP-4, linagliptin e lelefatsa ketso ea lihomone tsena tsa incretin, e leng se lebisang ho ntlafatseng taolo ea tsoekere ea mali ho batho ba nang le lefu la tsoekere la mofuta oa 2. Linagliptin ka tloaelo e laetsoe e le tlatsetso ea lijo le boikoetliso taolong ea lefu la tsoekere la mofuta oa 2.E tsebahala ka halofo ea eona e telele ea bophelo, e lumellang hore ho be bonolo ho nolofatsa dosing hang ka letsatsi.Ho lumeloa hore Linagliptin e fokotsa boemo ba hemoglobin A1c ka katleho, e leng letšoao la taolo ea nako e telele ea tsoekere, 'me hangata e mamelloa hantle ke bakuli. e ka ama bophelo ba batho ba nang le lefu la tsoekere la mofuta oa 2 haholo.Ka ho kenya letsoho ho thehoeng ha linagliptin sebopeho se ikhethang sa lik'hemik'hale, sena se bohareng se nolofalletsa sehlahisoa sa ho qetela hore se thibele DPP-4 ka katleho le ho ntlafatsa taolo ea glycemic. Qetellong, Linagliptin Intermediate F ke motsoako oa bohlokoa oa lik'hemik'hale motsoako oa linagliptin, DPP-4 inhibitor. e sebelisoa ho phekola lefu la tsoekere la mofuta oa 2.Karolo ea eona ho theheng sebopeho sa limolek'hule tsa linagliptin e totobatsa bohlokoa ba eona tlhahisong ea moriana o ka ntlafatsang taolo ea tsoekere ea mali le ho ntlafatsa taolo ea lefu la tsoekere.Ka ho thibela DPP-4, linagliptin e thusa ho laola maemo a tsoekere ea mali 'me e thusa ho phela hantle ka kakaretso ho batho ba nang le lefu la tsoekere la mofuta oa 2.