L-Tryptophan Cas: 73-22-3 99% Phofo e tšoeu
| Nomoro ea lethathamo | XD90295 |
| Lebitso la Sehlahiswa | L-Tryptophan |
| CAS | 73-22-3 |
| Foromo ea limolek'hule | C11H12N2O2 |
| Boima ba Molek'hule | 204.22518 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29339980 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99%mets |
| Ponahalo | Phofo e tšoeu |
| Kereiti | USP32 |
| Ho potoloha ho itseng | -29,4 ho ea ho -32,8 |
| pH | 5.5 ho isa ho 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Tahlehelo ka ho Omisa | <0.3% |
| Masalla a ho Ignition | 0.1%max |
| Cl | 0.05% boholo |
Indoleamine 2,3-dioxygenase (IDO1) le tryptophan 2,3-dioxygenase (TDO) ke li-enzyme tse peli tse sa tšoaneng tse nang le kabo e fapaneng ea lisele le mesebetsi ea 'mele, empa ka bobeli li susumetsa phetoho ea tryptophan ho N-formylkynurenine (NFK).IDO1 e netefalitsoe ka bongaka e le sepheo sa lithethefatsi tsa molek'hule tse nyane bakeng sa mofetše, ha lithuto tsa pele ho moo li bonts'a hore TDO e kanna ea ba sepheo sa mofets'e immunotherapy le lefu la neurodegenerative.Re entse tlhahlobo e phahameng ea tlhahlobo ea IDO1 le TDO e ipapisitseng le phuputso e ncha ea lik'hemik'hale, NFK Green, e sebetsanang ka ho khetheha le NFK ho theha molek'hule o motala oa fluorescent o nang le leqhubu la thabo la 400 nm le bophahamo ba maqhubu a 510 nm.Re fana ka papiso ea pele ka lehlakoreng le leng ea li-inhibitors tse 'maloa tse hatisitsoeng tsa IDO1 le TDO mme re senola hore IDO1 inhibitor Compound 5l ea pele e bonts'a ts'ebetso e kholo ea ts'ebetso le TDO, athe khetho e amanang ea li-inhibitors tse ling tse hatisitsoeng e netefalitsoe.Boikemisetso ba ho lekola litlhahlobo tse phahameng bo ile ba bontšoa ka ho hlahlobisisa laeborari ea lintho tsa lik'hemik'hale tse 87,000 ka sebopeho sa liliba tse 384 kapa 1536.Qetellong, re bonts'a hore tlhahlobo e ka boela ea sebelisoa ho lekanya matla a lisele ho metabolize tryptophan le ho lekanya matla a cellular a IDO1 le TDO inhibitors.
