Lihlahisoa

Ornithine aspartate e bile eona ea pele e sebelisoang tleliniking ho alafa lefu la lefuba le lefu la sebete.Ka pokello ea boiphihlelo ba ts'ebeliso ea bongaka, ornithine aspartate e sebelisitsoe haholo kalafong ea mafu a sebete, mme e fihletse litlamorao tse nepahetseng tsa kalafo ho lefu la sebete, tšenyo ea sebete e bakoang ke lithethefatsi, sebete se mafura, lefu la sebete le sa foleng le mafu a mang. e amoheloang ke lingaka.

Ornithine aspartate e fana ka substrate bakeng sa motsoako oa urea le glutamine ka vivo.Glutamine ke sehlahisoa sa detoxification sa ammonia, hammoho le mokhoa oa ho boloka le oa ho tsamaisa ammonia.Tlas'a maemo a 'mele le a pathological, motsoako oa urea le motsoako oa glutamine o angoa ke ornithine, aspartic acid le metsoako e meng ea dicarboxyl.Ornithine e ameha hoo e batlang e le ts'ebetsong eohle ea ts'ebetso ea potoloho ea urea le detoxification ea ammonia.Arginine e thehoa nakong ea ts'ebetso ena, 'me urea e aroloa ho etsa ornithine.Aspartic acid e kenya letsoho tlhahisong ea nucleic acid ho hepatocyte ho thusa ho lokisoa ha li-hepatocyte tse senyehileng.Ntle le moo, ka lebaka la nts'etsopele e sa tobang ea asiti ea aspartic ts'ebetsong ea metabolic ea tricarboxylic acid cycle liseleng tsa sebete, e khothalletsa tlhahiso ea matla liseleng tsa sebete, e thusang ho lokisoa ha lisele tse senyehileng tsa sebete le ho potlakisa ho hlaphoheloa ha sebete.Khatelo-pele ea morao-rao e bontšitse hore aspartate e ka boela ea thibela mosebetsi oa li-inflammasomes ka li-receptor tsa N-methyl-D-aspartate (NMDA), kahoo e fokotsa mokhoa oa phekolo ea phekolo ea ho ruruha ha sebete.Li-receptor tsa NMDA ke mofuta o ka tlase oa li-ionotropic excitatory glutamate receptors, tse bapalang karolo ea bohlokoa lits'ebetsong tsa 'mele joalo ka phetiso ea synaptic, polasetiki ea synaptic, ho ithuta le mohopolo tsamaisong ea methapo e bohareng.Lithuto tse latelang tsa pathological le tsona li netefalitse hore aspartate e ntlafalitse haholo liso tsa ho ruruha sebeteng.

Kopo ea bongaka

Lefapheng la lefu la sebete: Ornithine aspartate e sebelisoa haholo e le sethethefatsi se khahlanong le ho ruruha le hepatoprotective ho phekola maloetse a sa tšoaneng a sebete, a kang lefu la sebete la sebete, tšenyo ea sebete e bakoang ke lithethefatsi, sebete se mafura, lefu la sebete le sa foleng, joalo-joalo. mali ammonia ho bakuli ba nang le encephalopathy le ho imoloha ha matšoao a neuropsychiatric butle-butle ba fetoha moriana o ka sehloohong oa phekolo bakeng sa ho phekola mafu a sa tšoaneng a sebete.

Ornithine aspartate ke karolo ea bohlokoa ea motsoako oa urea le glutamine.Ornithine e ka kenya tšebetsong li-enzyme tsa bohlokoa ts'ebetsong ea urea synthesis - ornithine carbamoyltransferase le carbamoyl phosphate synthase, 'me e khothalletsa ammonia Metabolism ho fihlela detoxification ea mali ammonia, aspartic acid e le substrate e ka hlahisa glutamic acid le oxaloacetic acid, detoxification ke sehlahisoa sa glutamine. ammonia, hape ke polokelo le lipalangoang tsa ammonia.Oxaloacetate e kenya letsoho potolohong ea tricarboxylic acid, e khothalletsa tlhahiso ea matla liseleng tsa sebete, 'me e nolofalletsa lisele tsa sebete tse senyehileng hore li lokisoe, li nchafatsoe le ho tsosolosa tšebetso ea sebete.Ornithine aspartate e ka ntlafatsa ts'ebetso ea sebete ka katleho, ea fokotsa ammonia ea mali, 'me ea fokotsa ammonia ka lactulose le ofloxacin ka mokhoa o ts'oanang, ka hona, ea ntlafatsa haholo sekhahla sa pheko ea lefu la sebete la encephalopathy, le lokelang ho sebelisoa tleliniking.

Oncology: Ka liphetoho tse tsoelang pele mefuteng le litekanyetsong tsa litlhare tsa chemotherapy, mathata a amanang le litlhare tsa chemotherapy le ona a ntse a hlaha, mme tšenyo ea sebete ke e 'ngoe ea tšenyo e atileng haholo ea setho.Hang ha ts'enyo ea sebete e etsahala, e tla ama bophelo bo botle ba 'mele le ba kelello ba bakuli ka tekanyo e fapaneng, e sitise ts'ebetsong ea mekhoa ea phekolo ea lik'hemik'hale,' me e fokolise phello ea phekolo ea chemotherapy.Maemong a boima, ho hloleha ha sebete ho ka beha bophelo kotsing.Ornithine aspartate e ka ntlafatsa haholo tšenyo ea sebete e bakoang ke lithethefatsi tsa chemotherapy le ho ntlafatsa phello ea kalafo ea bakuli ba hlahala.

Sebaka sa ts'ebetso ea ho buoa: Ho buuoa ke ho otla litho tsohle tsa 'mele oa mokuli, 'me tšenyo ea ts'ebetso ea sebete ka mor'a ho buuoa le eona ke bothata bo tloaelehileng.Ornithine aspartate e ka thibela le ho phekola tšenyo ea sebete ka mor'a ho buuoa le ho khothalletsa ho hlaphoheloa ha bakuli ka mor'a ts'ebetso.