L-Glutamine Cas: 56-85-9 99% phofo e tšoeu
| Nomoro ea lethathamo | XD90309 |
| Lebitso la Sehlahiswa | L-Glutamine |
| CAS | 56-85-9 |
| Foromo ea limolek'hule | C5H10N2O3 |
| Boima ba Molek'hule | 146.1445 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29241900 |
Tlhaloso ea Sehlahisoa
| Mocheso oa polokelo | +20 likhato C |
| Boima ba Molek'hule | 146.14 |
| Tlhahlobo | 99.0% mets |
| Ponahalo | Phofo e tšoeu |
1.Early T-cell precursor leukemia (ETP-ALL) ke mofuta o ka tlaase oa kotsi ea leukemia ea batho e sa utloisisoeng hantle boemong ba molek'hule.Mona re tlaleha phetisetso e lebisitseng monoana oa zinki E-box-binding transcription factor ZEB2 e le leqeba le iphetang la lefutso ho immature/ETP-ALL.Re sebelisa mofuta oa toeba o nang le maemo, re bonts'a hore polelo e tsitsitseng ea Zeb2 e qala T-cell leukemia.Ho feta moo, leukemia ea mouse e tsamaisoang ke Zeb2 e bonts'a likarolo tse ling tsa signature ea motho e sa phethahalang / ETP-ALL gene, hammoho le bokhoni bo matlafalitsoeng ba ho qala leukemia le Janus kinase (JAK) / li-transducer tsa matšoao le li-activator tsa transcript (STAT) ts'ebetso ea transcriptal ea IL7R.Phuputso ena e senola ZEB2 e le onkogene ho baeloji ea immature/ETP-ALL 'me e bula tsela e lebisang lithutong tsa pele tsa bongaka tsa metsoako ea li-novel bakeng sa ho alafa mofuta ona o mabifi oa T-ALL oa motho o sebelisa mohlala oa rona oa mouse o tsamaisoang ke Zeb2.
2.Pluripotency, ho inchafatsa, le ho arohana ke likarolo tse khethehileng tsa lisele tsa embryonic stem (ES), kahoo li fana ka maikutlo a bohlokoa ka meriana ea ho tsosolosa.Mekhoa ea ntlafatso e hloka mokhatlo o hlophisitsoeng hantle, haholo-holo o laoloang ke litsela tse tsebahalang tsa JAK/STAT, PI3K/AKT, le ERK/MAPK.Li-SPREDs (Liprotheine tse amanang le limela tse nang le sebaka sa EVH1) li ile tsa fumanoa e le li-inhibitors tsa tsela ea pontšo ea ERK/MAPK, athe ha ho letho le neng le tsejoa ka mesebetsi ea bona liseleng tsa ES le nakong ea phapang ea pele, ho fihlela joale.Re hlahisitse SPRED1 le SPRED2 overexpressing le SPRED2 knockout murine ES lisele ho sekaseka mesebetsi ea liprotheine tsa SPRED liseleng tsa ES le nakong ea phapang ea pele.Ho feteletsa ha SPRED ho eketsa haholo ho inchafatsa le clonogenicity ea lisele tsa murine ES, athe ho hloka SPRED2 ho fokotsa ho ata le ho eketsa apoptosis.Nakong ea phapang ea pele ea 'mele ea embryoid, li-SPRED li khothalletsa boemo ba pluripotent le ho thibela phapang moo mesodermal d ifferentiation ho cardiomyocytes e liehang haholo le ho thibeloa.LIF- le kholo-factor-stimulation li senoletse hore SPREDs e thibela ts'ebetso ea ERK / MAPK liseleng tsa murine ES.Leha ho le joalo, ha ho liphello tse ileng tsa fumanoa ho ts'ebetsong e entsoeng ke LIF ea JAK / STAT3, kapa PI3K / AKT tsela ea pontšo ka liprotheine tsa SPRED. Tsela ea ho bonts'a MAPK liseleng tsa pluripotent.
