Lihlahisoa

Lefu la sebete sa mafura a se nang joala (NAFLD) le na le mefuta e mengata ea maloetse ho tloha ho steatosis e bonolo e khetholloang ke ho bolokoa ka mokhoa o sa tloaelehang oa lipids ka har'a lisele tsa sebete ho ea ho steatohepatitis (NASH) e bontšang ho bokellana ha mafura, ho ruruha, ballooning le ho senyeha ha li-hepatocytes, le fibrosis.Qetellong, steatohepatitis e ka fella ka ho thatafala ha sebete le lefu la sebete la sebete.Thuputsong ena re hlahlobile mefuta e meraro e fapaneng ea litoeba, A/J, C57BL/6J, le PWD/PhJ, e bontšang li-degree tse fapaneng tsa steatohepatitis ha li tsamaisoa 3,5-diethoxycarbonyl. -1,4-dihydrocollidine (DDC) e nang le lijo.Tlhahlobo ea polelo ea liphatsa tsa lefutso tsa RNA-Seq, tlhahlobo ea liprotheine le profiling ea metabolic li ile tsa sebelisoa ho tsebahatsa liphatsa tsa lefutso / liprotheine le maemo a ferekaneng a metabolite ea lisampole tsa sebete sa toeba nakong ea kalafo ea DDC.Tlhahlobo ea tsela e senola phetoho ea arachidonic acid (AA) le S-adenosylmethionine (SAMe) metabolism litseleng tse ling.Ho utloisisa liphetoho tsa metabolism ea arachidonic acid metabolism ho latela litlhaloso tsa lefu lena, mohlala oa kinetic oa tsela ena o ile oa ntlafatsoa mme oa ntlafatsoa ho latela maemo a metabolite.Ka mor'a moo, mohlala o ile oa sebelisetsoa ho ithuta ka liphello tsa silico tsa sepheo sa lithethefatsi tse ka 'nang tsa e-ba teng bakeng sa steatohepatitis.Re ile ra tsebahatsa metabolism ea AA / eicosanoid e ferekanngoa haholo ho litoeba tse bakoang ke DDC ho sebelisa motsoako oa mokhoa oa liteko le oa silico.Tlhahlobo ea rona ea tsela ea metabolic ea AA / eicosanoid e fana ka maikutlo a hore 5-hydroxyeicosatetraenoic acid (5-HETE), 15-hydroxyeicosatetraenoic acid (15-HETE) le prostaglandin D2 (PGD2) e ferekanngoa ho litoeba tsa DDC.Re boetse re bonts'a hore mohlala o matla o ka sebelisoa bakeng sa ho bolela esale pele ka boleng ba liphetoho tsa metabolic tse ipapisitseng le data ea transcriptomics maemong a amanang le lefu.Ho feta moo, SAMe metabolism e ile ea bonoa e ferekanngoa ka lebaka la kalafo ea DDC.Liphatsa tsa lefutso tse 'maloa hammoho le metabolite ea mojule ona li bontša phapang lipakeng tsa A/J le C57BL/6J ka lehlakoreng le leng le PWD/PhJ ka ho le leng.