Lihlahisoa

Lihlopha tsa tšepe-sulfur li sebetsa e le li-cofactors tsa mefuta e mengata ea liprotheine, tse nang le likarolo tse fapaneng tsa limolek'hule liseleng tsa prokaryotic le eukaryotic.Mechini e inehetseng e bokella lihlopha ebe e li isa ho limolek'hule tse amohelang ho qetela ka ts'ebetso e laoloang ka thata.Ka har'a prototypical Gram-negative bacteria Escherichia coli, litsamaiso tse peli tse teng tse teng tsa tšepe-sulphur cluster, iron-sulphur cluster (ISC) le sulfur assimilation (SUF) litsela tsa litsela li hokahane haholo.ISC pathway regulator, IscR, ke mokhoa oa ho ngola oa mofuta oa helix-turn-helix o ka hokahanyang sehlopha sa [2Fe-2S].Maemo a Redox le ho fumaneha ha tšepe kapa sebabole ho fetola boemo ba ligation ba sehlopha sa labile IscR, e leng sona se etsang qeto ea phetoho ho DNA ea tatellano e ikhethileng ea molaoli: IscR e nang le sehlopha e ka tlama lelapa la bahlahisi ba liphatsa tsa lefutso (mofuta-1) athe mofuta oa clusterless o lemoha feela sehlopha sa bobeli sa tatellano (mofuta-2).Leha ho le joalo, tšepe-sulfur cluster biogenesis ho libaktheria tsa Gram-positive ha e tsejoe hantle, 'me likokoana-hloko tse ngata tsa sehlopha sena li bonts'a e le' ngoe feela ea tsamaiso ea kopano ea tšepe-sulfur.Mokhelo o hlokomelehang ke tšepe e ikhethang ea Gram-positive dissimilatory e fokotsang baktheria Thermincola potens, moo liphatsa tsa lefutso tse tsoang lits'ebetsong ka bobeli li neng li ka tsejoa, leha ho na le mokhatlo o fapaneng le oa baktheria ea Gram-negative.Re bontšitse hore e 'ngoe ea liphatsa tsa lefutso tsena e kenyelletsa homolog e sebetsang ea IscR 'me ho ka etsahala hore e kentse letsoho taolong ea "iron-sulfur cluster biogenesis" ho T. potens.Sebopeho sa sebopeho le lik'hemik'hale tsa lik'hemik'hale tsa T. potens le E. coli IscR li senotse meralo e ts'oanang ka mokhoa o tsotehang 'me ea senola paballo e sa lebelloang ea mokhoa o ikhethang oa khethollo ea tatellano e khethollang sehlopha sena se ikhethileng sa balaoli ba mongolo.