Lihlahisoa

7-Hydroxygranisetron ke motsoako o sebetsang e le meriana lefapheng la meriana.Ke ea sehlopha sa lithethefatsi tse tsejoang e le bahanyetsi ba li-receptor tsa serotonin 5-HT3.Motsoako ona ke metabolite ea granisetron, sethethefatsi se sebelisoang hangata sa antiemetic.Sepheo se seholo sa 7-Hydroxygranisetron ke ho thibela le ho phekola ho nyekeloa ke pelo le ho hlatsa, haholo-holo tse amanang le chemotherapy kapa mekhoa ea ho buuoa.Chemotherapy-induced nausea and vomiting (CINV) ke ntho e amehang haholo ho bakuli ba kankere ba ntseng ba phekoloa.Litla-morao tsena li ka ama bophelo ba mokuli hampe 'me li ka baka tšitiso ea kalafo.7-Hydroxygranisetron e sebetsa ka ho thibela li-receptor tse khethehileng tsa serotonin tsamaisong ea methapo e bohareng, haholo-holo tse sebakeng sa chemoreceptor trigger zone le setsi sa ho hlatsa.Ka ho etsa joalo, e thusa ho fokotsa matšoao a bakang ho nyekeloa ke pelo le ho hlatsa, ho fana ka phomolo ho bakuli.Ho phaella ho tšebeliso ea eona bakeng sa CINV, 7-Hydroxygranisetron e boetse e bontšitse tšepiso ea ho laola ho nyekeloa ke pelo le ho hlatsa ka mor'a ts'ebetso (PONV).Ka mor'a mekhoa ea ho buuoa, bakuli ba atisa ho ba le bothata ba ho nyekeloa ke pelo le ho hlatsa ka lebaka la liphello tsa anesthesia le lintlha tse ling.7-Hydroxygranisetron e thusa ho thibela le ho laola matšoao ana, ho lumella bakuli hore ba hlaphoheloe hamonate.Tekanyetso e ka fapana ho ipapisitsoe le lintlha tse kang boima ba motho, mokhoa o itseng kapa kalafo, le ho teba ha matšoao.Ke habohlokoa ho latela tekanyo e behiloeng le litaelo tse fanoeng ke litsebi tsa tlhokomelo ea bophelo ho netefatsa katleho e nepahetseng le ho qoba litla-morao leha e le life tse ka 'nang tsa e-ba teng.Joaloka meriana e mengata, 7-Hydroxygranisetron e ka ba le litla-morao tse ka bang teng.Tsena li ka kenyelletsa hlooho, pipitlelano, letšollo, ho tsekela le ho khathala.Maemong a sa tloaelehang, batho ba ka 'na ba e-ba le maikutlo a ho kula kapa liphello tse matla le ho feta.Ke habohlokoa ho tlaleha leha e le efe e amanang le matšoao kapa liketso ho mofani oa tlhokomelo ea bophelo bakeng sa tlhahlobo le tsamaiso e nepahetseng.Qetellong, 7-Hydroxygranisetron ke meriana e sebelisoang haholo-holo ho thibela le ho phekola ho nyekeloa ke pelo le ho hlatsa tse amanang le chemotherapy le mekhoa ea ho buuoa.Ka ho thibela li-receptor tse ling tsa serotonin tsamaisong ea methapo e bohareng, e thusa ho fokotsa matšoao ana a sithabetsang ho bakuli ba mofetše le batho ka bomong ba hlaphoheloang ho tsoa opereishene.Leha ho le joalo, joalo ka meriana leha e le efe, eona