GLYCYL-L-PROLINE Cas:704-15-4 99% Powde e tšoeu
| Nomoro ea lethathamo | XD90153 |
| Lebitso la Sehlahiswa | GLYCYL-L-PROLINE |
| CAS | 704-15-4 |
| Foromo ea limolek'hule | C7H12N2O3 |
| Boima ba Molek'hule | 172.18 |
| Lintlha tsa polokelo | Lebenkele ho RT |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu |
| Assay | ≥ 99% |
| Botenya | 1.356±0.06 g/cm3 (20 ºC 760 Torr), |
| Sebaka se qhibilihang | 185 ºC |
| Ntho e belang | 411.3°C ho 760 mmHg |
| Lenane la refractive | -114 ° (C=4, H2O) |
| Solubility | qhibilihang habonolo (260 g/L) (25 ºC), |
Mekhoa ea 1.Metabolite profiling ke lisebelisoa tsa bohlokoa tsa ho lekanya matamo a metabolite tsamaisong ea likokoana-hloko.Le hoja mekhoa e mengata ea ho hlahisa metabolite e tlaleha matla a amanang kapa e itšetlehile ka litekanyetso tse seng kae tsa ka hare tse emelang metabolite eohle, tlhokahalo ea ho qetela bakeng sa tlhaloso ea palo ea letamo la metabolite liseleng tsa likokoana-hloko le maro ke boikemisetso bo feletseng ba mahloriso.Mona re tlaleha mokhoa o hlakileng oa chromatography/tandem mass spectrometry (GC/MS/MS) e lebisitsoeng ho metabolite e lumellang hore ho be le palo e felletseng ea metabolite eohle e fumanoeng.Mokhoa ona o ipapisitse le methyl chloroformate derivatization le quantification ka lisampole tsa spiking tse nang le litekanyetso tsa metabolite tse nkiloeng ka thoko ka li-reagents tsa deuterated derivatization.Ionization ea tloaelo ea elektronike e nkeloa sebaka ke ionization ea lik'hemik'hale tse ntle kaha ea morao-rao ho isa tekanyong e kholoanyane e boloka ion ea molek'hule le likaroloana tse ling tse phahameng tsa boima ba limolek'hule.Sena se ile sa etsa hore ho be bonolo ho khetha liphetoho tse ikhethang tsa MS/MS har'a li-metabolite tse ngata tse kopanyang.Hajoale, mokhoa o mocha oa GC/MS/MS o na le metabolite ea mantlha e tloaelehileng ea 67 eo boholo ba eona e leng tsa lihlopha tsa amino le nonamino organic acid.Re bonts'a ts'ebetso ea mokhoa ona ho lisampole tsa moroto le serum.Mokhoa ona ke ntlafatso e kholo ea mokhoa oa hajoale oa profiling ea GC/MS metabolite ea li-amino acid le li-nonamino organic acid.
2.24S-Hydroxycholesterol (24OHC) le 27-hydroxycholesterol (27OHC) ke li-oxysterol tse peli tse tšoanang ka sebopeho tse fapaneng - ea pele e neng e batla e entsoe ka bokong feela 'me ea morao e entsoe ka tekanyo e nyenyane bokong ho feta litho tse ling tse ngata.HO HLOKAHALA HO LEKOA: Tšenyo ea methapo ea kutlo le/kapa demyelination e baka phallo e ntseng e eketseha ea 24OHC ho tloha bokong ho ea ho cerebrospinal fluid (CSF), athe sekoli se thibelang mali bokong se baka phallo e eketsehileng ea 27OHC ho tloha ho potoloha ho ea CSF.Isotope dilution-mass. spectrometry e ne e sebelisetsoa ho hlahloba li-oxysterol tse peli ho CSF le plasma ho tsoa ho bakuli ba fetang 250 ba nang le mafu a fapaneng a methapo ea pelo le ea geriatric. Litekanyo tsa CSF tsa li-oxysterol tse peli li ne li amehile haholo ke mafu a sa tšoaneng ho feta maemo a plasma.Bakuli ba nang le mafu a sebetsang a demyelinating ba ne ba eketsehile litekanyetso tsa 24OHC ho CSF ka karolelano e batlang e le 24OHC / 27OHC.Bakuli ba nang le meningitis ka kakaretso ba ne ba e-na le litekanyetso tse phahameng tsa li-steroid ka bobeli tse nang le tekanyo e tlaase ea 24OHC/27OHC.Bakuli ba nang le lefu la Alzheimer ba ne ba eketsehile hanyane ka hanyane maemong a 24OHC ho CSF ka keketseho e nyane ho 27OHC.Bakuli ba nang le multiple sclerosis ba ne ba e-na le tšekamelo ea ho ba le maemo a phahameng a 24OHC nakong ea nako e sebetsang ka tekanyo e phahameng ea 24OHC / 27OHC. Litekanyo tsa li-oxysterol tse peli ho CSF le plasma li ka eketsa haholo mekhoa e teng ea biochemical bakeng sa ho hlahloba mafu a methapo ea methapo.
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