Lihlahisoa

Islet amyloid polypeptide (IAPP; e tsejoang hape e le amylin) e ikarabella bakeng sa sebopeho sa islet amyloid mofuteng oa 2 lefu la tsoekere, 'me chefo e bakoang ke IAPP ho lumeloa hore e kenya letsoho tahlehelong ea boima ba β-cell e amanang le mekhahlelo ea morao-rao ea lefu la tsoekere la mofuta oa 2.Sebopeho sa Islet amyloid se ka boela sa phetha karolo ea ho hlōleha ha graft ka mor'a ho kenngoa.IAPP e hlahisoa e le prohormone, pro-islet amyloid polypeptide (proIAPP), 'me e sebetsoa ka li-granules tsa sephiri tsa pancreatic β-cell.Mefuta e entsoeng ka mokhoa o sa fellang ea proIAPP e fumanoa ho li-amyloid deposits;e hlokomelehang haholo ke 48-residue intermediate, proIAPP(1-48), e kenyeletsang N-terminal pro-extension, empa e sebetsitsoeng hantle C-terminus.Ts'ebetso e sa phethoang e ka 'na ea phetha karolo ea ho thehoa ha li-islet amyloid ka ho khothalletsa ho sebelisana le sulfated proteoglycans ea extracellular matrix, e leng eona e khothalletsang ho thehoa ha amyloid.Re bontša hore acid fuchsin (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), e bonolo. sulfonated triphenyl methyl derivative, ke inhibitor e matla ea sebopeho sa amyloid ke proIAPP(1-48) e bohareng.Mofuta o rarahaneng haholoanyane oa triphenyl methane e tsoang ho FCF e tala ka potlako {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl] -(4-hydroxy-2-sulfophenyl)methylidene] -1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl) methyl]azanium} e boetse e thibela ho thehoa ha amyloid ke IAPP le proIAPP processing intermediate.Metsoako ka bobeli e thibela sebopeho sa amyloid ka metsoako ea proIAPP ea mahareng le ea mohlala glycosaminoglycan heparan sulfate.Acid fuchsin e boetse e thibela sebopeho sa glycosaminoglycan-mediated amyloid ke IAPP e hōlileng tsebong.Bokhoni ba ho thibela sebopeho sa amyloid ha se feela ka lebaka la metsoako ea sulfonated, kaha sulfonated inhibitor ea amyloid-β, tramiprosate, hase inhibitor ea sebopeho sa amyloid ka proIAPP (1-48).