Lihlahisoa

Phello ea acidosis, e leng letšoao la biochemical ea tumor microenvironment, tsoelo-peleng ea mofetše le metastasis e rarahane.Bobeli litlamorao tsa acidosis le tse khahlanong le tumor li tlalehiloe 'me tikoloho ea acidic e sebelisitsoe hampe bakeng sa phano e khethehileng ea lithethefatsi, li-imaging agents, le liphatsa tsa lefutso tse hahang lihlahala.Thutong ena re batlisisa ka ho ata le ho tsepama ha lisele tsa melanoma tsa B16F10 tse entsoeng ka liphatsa tsa lefutso ho fetisa pH-sensing G protein-coupled receptor GPR4.Ka ho sebelisa litlhahlobo tsa li-cell attachment re fumane hore GPR4 e liehile ho ata ha lisele le ho fetola sebaka sa sebaka sa matla a ho khomarela, joalo ka ha phosphorylated focal adhesion kinase (FAK) le paxillin, acidic pH.Litsela tse ka bang teng tsa G-protein le litsela tse tlase tse ikarabellang bakeng sa litlamorao tsena le tsona li ile tsa fuputsoa.Ka ho sebelisa Rho inhibitor CT04 (C3 transferase), Rho-associated kinase (ROCK) inhibitors Y27632 le thiazovivin, myosin light chain kinase (MLCK) inhibitor staurosporine kapa G12/13 inhibitory construct, ho ata ha sele ho ile ha tsosolosoa empa ts'ebetso ea litsela tsa Gq le Gs e bile le phello e fokolang kapa e se nang letho.Ka kakaretso liphetho tsa rona li bontša hore ka tsela ea G12 / 13 / Rho GPR4 e fetola matla a ho khomarela 'me e fokotsa ho ata ha lisele le ho phunyeha ha membrane.