Dirhodium tetraacetate CAS: 15956-28-2 99% Likristale tse botala-botšo
| Nomoro ea lethathamo | XD90641 |
| Lebitso la Sehlahiswa | Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| Foromo ea limolek'hule | C8H12O8Rh2 |
| Boima ba Molek'hule | 441.987 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 28439000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Likristale tse botala-botšo |
| Tlhahlobo | 99% |
Litšebelisano tse tlamang tsa equatorial N7/O6 tsa antitumor active complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) ka sekhechana sa DNA d(GpG) li khethiloe ka mokhoa o hlakileng ke spectroscopy ea NMR.Liqeto tse fetileng tsa X-ray tsa crystallographic tsa hlooho-ho-hlooho (HH) le hlooho-to-mohatla (HT) li-adducts tsa dirhodium tetraacetate e nang le 9-ethylguanine (9-EtGH) e senotse borokho bo neng bo e-s'o ka bo e-ba teng ba N7/O6 guanine nucleobases tse fetang Rh. -Rh tlamo.Ho ba sieo ha protonation ea N7 ho pH e tlase le keketseho e hlokomelehang ea acidity ea N1-H (pK(a) hoo e ka bang 5.7 ha e bapisoa le 8.5 bakeng sa li-adducts tsa platinum tse tlamang N7 feela), tse hlahisitsoeng ke ho itšetleha ha pH ea purine H8 (1). )H NMR resonances bakeng sa Rh(2)(OAc)(2)(9-EtG)(2) le Rh(2)(OAc)(2-)[d(GpG)],a lumellana le bidentate N7/O6 e tlamang li-nucleobase tsa guanine.Boleng ba pK(a) bo hakantsoeng bakeng sa N1-H (de) protonation, ho tsoa liphuputsong tsa ho itšetleha ka pH tsa C6 le C2 (13)C NMR resonances bakeng sa Rh(2)(OAc)(2)(9-EtG)( 2) li-isomers, li lumellana le t hose e nkiloeng ho H8 (1)H NMR resonance titrations.Papiso ea (13) C NMR resonances ea C6 le C2 bakeng sa dirhodium adducts Rh (2) (OAc) (2) (9-EtG) (2) le Rh (2) (OAc) (2)[d(GpG) )] e nang le li-resonances tse lumellanang tsa li-ligands tse sa tlamisoang [ho pH 7.0 bakeng sa 9-EtGH le pH 8.0 bakeng sa d (GpG)], e bonts'a liphetoho tse kholo tsa Deltadelta hoo e ka bang 11.0 le 6.0 ppm bakeng sa C6 le C2, ka ho latellana;liphetoho tsa morao-rao li bontša phello ea O6 e tlamang litsi tsa dirhodium le ntlafatso e latelang ea acidity ea N1-H.Litlhōrō tse matla tsa H8/H8 ROE ho 2D ROESY NMR spectrum ea Rh(2)(OAc)(2)[d(GpG)] li bontša tlhophiso ea hlooho-ho-hlooho ea metheo ea guanine.Thepa ea Rh(2)(OAc)(2)[d(GpG)] e bonts'a li-conformer tse peli tse ka ho le letona, HH1 R le HH2 R, HH1 R e ngata haholo ho feta HH2 R e sa tloaelehang. li-adducts li senotse ho lahla li-rings tsa tsoekere tsa 5'-G ho C3'-endo (N-mofuta), ho bolokoa ha C2'-endo (S-type) conformation bakeng sa 3'-G sugar ring gs, le anti orientation mabapi le li-bond tsa glycosyl.Likarolo tsa sebopeho tse fumanoeng bakeng sa Rh(2)(OAc)(2))[d(GpG)] ka NMR spectroscopy li tšoana haholo le tsa cis-[Pt(NH(3)))(2))[d( GpG)]] le ho tiisa lithuto tsa mohlala oa limolek'hule.
