Lihlahisoa

Clopidogrel camphorsulfonate ke motsoako oa meriana o nang le foromo ea lik'hemik'hale C16H16ClNO2S·C10H16O4S.Hangata e tsejoa e le Clopidogrel S-oxide camphorsulfonate kapa Clopidogrel CAMS.Motsoako ona ke motsoako oa chiral oa clopidogrel, e leng meriana ea antiplatelet e sebelisoang haholo.Tšebeliso e ka sehloohong ea Clopidogrel camphorsulfonate ke motsoako o sebetsang ha ho etsoa lithethefatsi tsa antiplatelet.E sebetsa ka ho thibela ho kopana ha platelet, ho thibela ho thehoa ha lesela la mali, le ho fokotsa kotsi ea liketsahalo tsa pelo.Motsoako o lebisa ka ho khetheha mokelikeli oa P2Y12 ho li-platelet, kahoo o thibela ts'ebetso ea ts'ebetso le ho thibela ho kopana ha platelet.Mokhoa ona oa ts'ebetso o etsa hore Clopidogrel camphorsulfonate e atlehe ho thibela arterial thrombosis le ho fokotsa liketsahalo tse mpe tsa pelo le methapo ea mali, ho kenyelletsa le tlhaselo ea pelo le stroke.Clopidogrel camphorsulfonate hangata e tsamaisoa ka molomo ka mokhoa oa matlapa kapa li-capsules.Hang ha e kenngoa, e fetoha phetoho ea metabolic sebeteng, e leng se etsang hore ho thehoe metabolite e sebetsang.Metabolite ena e sebetsang ebe e tlama ka mokhoa o ke keng oa fetoloa ho receptor ea P2Y12, e fana ka litlamorao tsa eona tsa antiplatelet nako e telele.Nakong ea tleliniki, Clopidogrel camphorsulfonate hangata e laeloa bakuli ba nang le lefu la pelo, joalo ka angina e sa tsitsang le infarction ea myocardial, kapa ba nang le lefu la pelo. ho kenella (PCI) ka ho beoa ha stent.E boetse e sebelisoa haholo ho thibela ketsahalo ea liketsahalo tsa thrombotic ho bakuli ba nang le histori ea lefu la stroke kapa peripheral artery disease.Ke habohlokoa ho hlokomela hore Clopidogrel camphorsulfonate e lokela ho sebelisoa feela tlas'a tlhokomelo ea setsebi sa bophelo bo botle, kaha e ka 'na ea sebelisana le meriana e meng kapa e na le li-contraindications ka linako tse ling. baahi ba bakuli.Tekanyetso le nako ea kalafo li ka fapana ho latela boemo ba bongaka ba motho, 'me ho ka hlokahala hore ho behoe leihlo khafetsa ts'ebetso ea platelet le liteko tsa mali ho netefatsa phello e nepahetseng ea kalafo. haholo-holo ba nang le arterial thrombosis.Thepa ea eona ea antiplatelet le ho thibela ho khetholla ha P2Y12 receptor e etsa hore e be meriana e sebetsang bakeng sa ho fokotsa kotsi ea liketsahalo tse mpe tsa pelo.Leha ho le joalo, joalo ka motsoako ofe kapa ofe oa meriana, tlhokomelo e lokela ho sebelisoa ha e sebelisoa, 'me bakuli ba lokela ho khomarela litlhahiso le tataiso ea mofani oa bona oa tlhokomelo ea bophelo.