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5,6-Dihydro-3- (4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H) -pyridinone CAS: 545445-44-1
| Nomoro ea lethathamo | XD93344 |
| Lebitso la Sehlahiswa | 5,6-Dihydro-3-(4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H) -pyridinone |
| CAS | 545445-44-1 |
| Foromo ea molek'hulela | Setšoantšo sa C20H25N3O3 |
| Boima ba Molek'hule | 355.43 |
| Lintlha tsa polokelo | Ambient |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu |
| Assay | 99% mets |
5,6-Dihydro-3- (4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl) phenyl] -2 (1H) -pyridinone, e tsejoang hape e le DMPHP, ke motsoako oa heterocyclic o nang le mekhoa e sa tšoaneng. k'hemistri ea meriana le ho sibolloa ha lithethefatsi.Mona ke tlhaloso ea tšebeliso ea eona ka mantsoe a ka bang 300. DMPHP e tsejoa ka bokhoni ba eona e le inhibitor e matla le e khethollang ea li-enzyme le li-receptor tse itseng 'meleng oa motho.E 'ngoe ea likopo tsa eona tse ka sehloohong ke tšimong ea kinase inhibition.Kinase ke li-enzyme tse bapalang karolo ea bohlokoa mekhoeng ea matšoao a lisele mme hangata li ameha mafung a fapaneng, ho kenyeletsoa mofetše.DMPHP e fumanoe e thibela li-kinase tse khethehileng ka mokhoa o ikhethileng, ka hona e sitisa li-cascade tse sa tloaelehang tse tlatsetsang tsoelo-peleng ea mafu.Sena se etsa hore e be mokhethoa ea tšepisang bakeng sa nts'etsopele ea mekhoa ea phekolo e lebisitsoeng bakeng sa mefuta e mengata ea mafu, ho akarelletsa le kankere, ho ruruha, le mathata a methapo ea kutlo.Ho feta moo, DMPHP e bontšitse bokhoni sebakeng sa ts'ebetso e khahlanong le ho ruruha le ea immunomodulatory.Ho ruruha ke karabelo ea tlhaho ea 'mele ho tšoaetso kapa kotsi empa e ka fetoha e sa foleng' me ea baka mafu a sa tšoaneng.DMPHP e bontšitse bokhoni ba ho thibela litsela tse itseng tse thibelang ho ruruha, ho fokotsa tlhahiso ea bakena-lipakeng ba ho ruruha.Thepa ena e etsa hore e be sesebelisoa sa bohlokoa ho nts'etsopele ea lithethefatsi tse thibelang ho ruruha, tse thusang ho phekola maemo a kang ramatiki ea ramatiki, lefu la ho ruruha ha mala, le asthma. .Bohloko bo sa foleng ke taba ea bohlokoa ea bophelo bo botle, 'me mekhoa ea hona joale ea phekolo hangata e na le mefokolo kapa litla-morao tse sa batleheng.DMPHP e bontšitse liphello tsa analgesic liphuputsong tsa preclinical, e fana ka maikutlo a bokhoni ba eona e le mokhoa o mocha oa phekolo bakeng sa ho laola bohloko.Ka ho fetola li-receptors tse khethehileng le li-neurotransmitters tse amehang maikutlong a bohloko, DMPHP e ka fana ka mokhoa o mong oa ho laola bohloko o nang le litla-morao tse ka 'nang tsa fokotseha.Ho phaella moo, DMPHP e bontšitse tšepiso tšimong ea mathata a tsamaiso ea methapo ea bohareng (CNS).Maemo a methapo ea kutlo joalo ka lefu la Alzheimer le lefu la Parkinson a kenyelletsa mekhoa e rarahaneng le ho senyeha ha li-receptor tse fapaneng le li-enzyme bokong.DMPHP e hlahlobiloe ka bokhoni ba eona ba ho ba moemeli oa methapo ea kutlo le bokhoni ba eona ba ho ntlafatsa ts'ebetso ea kelello.Ka ho lebisa tlhokomelo e khethehileng ea li-receptors le litsela tse amehang ho mafu a neurodegenerative, DMPHP e na le ts'episo e le ts'ebetso ea phekolo bakeng sa maemo ana a thata. 1-piperidinyl)phenyl] -2(1H) -pyridinone (DMPHP) ke motsoako o nang le mekhoa e mengata e nang le lisebelisoa tse ka sebelisoang ho thibela kinase, ts'ebetso e khahlanong le ho ruruha, analgesia, le neuroprotection.Bokhoni ba eona ba ho khetha li-enzyme le li-receptor tse amehang litseleng tsa mafu li etsa hore e be mokhethoa ea khahlehang bakeng sa ho sibolloa ha lithethefatsi le ho kenella kalafong.Liphuputso tse ling le nts'etsopele li ka senola ts'ebeliso e eketsehileng le ho ntlafatsa thepa ea eona bakeng sa matšoao a ikhethileng.
