Lihlahisoa

5-Nitrouracil ke motsoako oa lik'hemik'hale o fumanang ts'ebetso likarolong tse 'maloa, ho kenyelletsa le meriana, biochemistry, le meriana.Ke motsoako oa uracil, nucleobase eo e leng karolo ea bohlokoa ea RNA.Ka meriana, 5-Nitrouracil e bontšitse likopo tse tšepisang e le moemeli oa anticancer.E sebetsa ka ho thibela tlhahiso ea DNA le RNA, ka hona e sitisa kholo le ho ikatisa ha lisele tsa mofetše.Ka ho shebana le lisele tse arohaneng ka potlako, e ka sebelisoa ho phekola mefuta e fapaneng ea mofetše, ho kenyeletsoa mofetše oa colorectal, oa matsoele le oa mala.Liphuputso li boetse li bontšitse hore 5-Nitrouracil e ka sebetsa hammoho le li-chemotherapeutic agents tse ling, ho ntlafatsa liphello tsa bona tsa anticancer.Tšebeliso e 'ngoe ea bohlokoa ea 5-Nitrouracil e tšimong ea biochemistry.E sebelisoa haholo e le probe ea limolek'hule kapa substrate litekong tsa enzyme le lithutong tsa biochemical.Mohlala, e ka sebelisoa ho ithuta ka tšebetso ea enzymatic e amehang ho metabolism ea nucleotide, joalo ka ts'ebetso ea uracil phosphoribosyltransferase.Ho kenngoa ha eona ho nucleic acids ho boetse ho sebelisitsoe ho batlisisa liphello tsa metheo e fetotsoeng holim'a sebopeho sa DNA le mosebetsi.Ho feta moo, 5-Nitrouracil e 'nile ea batlisisoa bakeng sa tšebeliso ea eona e ka sebelisoang e le moemeli oa letsatsi.E na le thepa ea ho monya UV, e ka thusang ho sireletsa letlalo mahlaseling a kotsi a ultraviolet (UV).Thepa ena e tsoa ho li-conjugated litlamo tse peli tse teng mohahong oa eona, e lumellang hore e monye leseli la UV le ho thibela ho kenella ha eona likarolong tse tebileng tsa letlalo. metsoako.E ka sebelisoa e le selelekela sa tlhahiso ea lithethefatsi tse thibelang kankere le lisebelisoa tse ling tsa meriana.Ho fumaneha ha eona le bokhoni ba ho sebetsana le lik'hemik'hale tse sa tšoaneng tsa lik'hemik'hale ho etsa hore e be sesebelisoa sa bohlokoa ho nts'etsopele ea lithethefatsi tse ncha le metsoako ea phekolo.Mehato e nepahetseng ea tšireletso, e kang ho roala liatlana le ho sebetsa sebakeng se nang le moea o motle, ho lokela ho lateloa ho fokotsa kotsi ea ho pepeseha.Qetellong, 5-Nitrouracil ke motsoako o nang le mefuta e fapaneng ea likopo tsa meriana, biochemistry, le meriana.Litšobotsi tsa eona tsa anticancer li e etsa motho ea ka bang teng bakeng sa kalafo ea mofets'e, 'me thepa ea eona ea biochemical e etsa hore e sebelisoe joalo ka probe ea limolek'hule le substrate lithutong tse fapaneng tsa enzymatic.Ho feta moo, thepa ea eona ea ho monya UV e e beha e le motsoako o ka bang teng oa ho etsa litlolo tse sireletsang letsatsi.Ho feta moo, karolo ea eona e le selelekela sa motsoako oa metsoako ea meriana e totobatsa bohlokoa ba eona ntlafatsong ea lithethefatsi.Ho sebetsana ka hloko le ho latela litataiso tsa polokeho ho bohlokoa ha o sebetsa le 5-Nitrouracil.