Lihlahisoa

Li-n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) le docosahexaenoic acid (DHA) li bontšitsoe ho ntlafatsa phello ea meriana ea chemotherapeutic lithutong tsa bongaka ho bakuli ba mofetše le ho etsa hore lisele tsa apoptotic lefu le shoe ka har'a vitro.Ho fihlela joale, EPA le DHA ha li so ka li etsoa lipatlisiso ho multiple myeloma (MM).Lisele tsa myeloma tsa batho (L363, OPM-1, OPM-2 le U266) le lisele tse tloaelehileng tsa mali tsa mononuclear tsa mali li ile tsa pepesetsoa EPA le DHA, 'me liphello tsa ts'ebetso ea mitochondrial le apoptosis, ts'ebetso ea caspase-3, liphatsa tsa lefutso le chefo ea lithethefatsi li ile tsa lekanngoa.Ho pepesehela EPA le DHA ho entse hore ho be le apoptosis le ho eketseha ha kutloisiso ho bortezomib liseleng tsa MM.Habohlokoa, ha lia ka tsa ama bokhoni ba lisele tse tloaelehileng tsa peripheral mononuclear.Melaetsa ea RNA ea polelo ea Messenger e bonts'itse hore EPA le DHA li fetotse liphatsa tsa lefutso tse amehang litseleng tse ngata tsa matšoao ho kenyelletsa nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress le Wnt.EPA le DHA li ile tsa thibela ts'ebetso ea NFκB le ho kenya apo ptosis ka ho ferekana ha mitochondrial le caspase-3 activation.Boithuto ba rona bo fana ka maikutlo a hore EPA le DHA li etsa hore ho be le litlamorao tse ikhethileng tsa cytotoxic ho MM le ho eketsa kutloelo-bohloko ho bortezomib mme e batla hore ho etsoe lipatlisiso tse eketsehileng mabapi le ts'ebeliso e ka bang teng ea li-n-3 polyunsaturated fatty acids kalafong ea MM.