5-Iodo-2'-deoxycytidine CAS: 54-42-2 98-102% phofo e tšoeu ea kristale
| Nomoro ea lethathamo | XD90562 |
| Lebitso la Sehlahiswa | 5-Iodo-2'-deoxycytidine |
| CAS | 54-42-2 |
| Foromo ea limolek'hule | C9H11IN2O5 |
| Boima ba Molek'hule | 354.10 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu ea kristale |
| Tlhahlobo | 99% |
| Ho potoloha ho itseng | +25 ho isa ho +30 |
| Litšepe tse boima | <0.001% |
| Tahlehelo ka ho Omisa | <1.0% |
| Masalla a ho Ignition | <0.3% |
Sebopeho sa 3D se ka boleloang esale pele sa DNA e nang le likarolo tse peli se etsa hore e tšoanelehe e le template bakeng sa moralo o ka tlase oa libaka tse sebetsang tse thehiloeng ho nucleic acid.Mona re hlahloba tšebeliso ea 14mer DNA duplex e le scaffold bakeng sa boemo bo nepahetseng le bo ka lebelloang ba ts'ebetso ea ts'ebetso.Ka lebaka la ho kenya letsoho hohle ha sehlopha sa imidazole se thehiloeng ho histidine ka ho lemoha liprotheine le liketsahalo tsa catalysis, ho ile ha fuputsoa li-duplexes tse fetotsoeng tse kang histidine.Ho kopanya histamine ho C5 ea motheo oa thymine ka bond ea amide, ho lumella boemo bo feto-fetohang ba mosebetsi oa imidazole ka har'a groove e kholo.Litšebelisano tse kopanetsoeng pakeng tsa imidazole le duplex le tšusumetso ea eona ho imidazolium pKaH li hlahlojoa ka ho beha thymine e le 'ngoe e fetotsoeng libakeng tse' nè tse fapaneng bohareng ba 14mer double helix.Ho sebelisa NMR le mekhoa e sa tsitsang ea limolek'hule, ho thehoa sebopeho sa hydrogen bond pakeng tsa imidazole le Hoogste ea li-guanine tsa lihlopha tse peli tse haufi tsa GC tse haufi.Sepheo se tlatsetsa ho tsitsisa khahlanong le ho qhibiliha ha mocheso oa 6 ° C 'me ke senotlolo sa ho fetola pKaH ea sehlopha sa imidazolium.Likarolo tse akaretsang, lintho tse hlokahalang pele le sebopeho se akaretsang sa "pKaH-regulating motif" e hlalositsoe.
