Lihlahisoa

4-Chlorophenylboronic acid ke motsoako oa organic o fumanang ts'ebeliso e pharaletseng mafapheng a fapaneng, ho kenyeletsoa organic synthesis, chemistry ea bongaka, le mahlale a thepa.E na le selikalikoe sa phenyl se nkeloang sebaka ke sehlopha sa chloro (-Cl) le sehlopha sa boronic acid (-B (OH) 2) . E 'ngoe ea lisebelisoa tse ka sehloohong tsa 4-Chlorophenylboronic acid ke karolo ea eona e le reagent ea bohlokoa ho palladium-catalyzed. karabelo e kopanyang, joalo ka karabelo ea Suzuki-Miyaura le Heck.Liphetoho tsena li kenyelletsa ho thehoa ha carbon-carbon bonds, moo 4-Chlorophenylboronic acid e sebetsang e le mohloli oa boron o ka kopanang le mefuta e sa tšoaneng ea li-electrophiles, tse kang aryl kapa vinyl halides.Sena se nolofalletsa ho kopanya mefuta e sa tšoaneng ea metsoako ea lintho tse phelang, ho akarelletsa le meriana, agrochemicals, le thepa.Mohlala, e ka ba le karabelo ea amination ho theha 4-chloro-phenylboronates, e ka bang lipakeng tsa bohlokoa bakeng sa ho kopanya metsoako e fapaneng e nang le naetrojene.Phapang ena ea sehlopha se sebetsang e ntlafatsa ts'ebeliso ea maiketsetso ea 4-Chlorophenylboronic acid, e lumellang hore ho thehoe limolek'hule tse rarahaneng tse nang le thepa e entsoeng.Kopo e 'ngoe ea bohlokoa ea 4-Chlorophenylboronic acid e itšetlehile ka lik'hemik'hale tsa meriana.E bontšitse tšepiso e le pharmacophore kapa mohaho oa mohaho bakeng sa ho hlahisa metsoako ea bioactive.Ka lebaka la karolo ea boronate, 4-Chlorophenylboronic acid e ka theha maqhama a covalent a fetohang le limolek'hule tse nang le diol, joalo ka lik'habohaedreite le li-nucleotide.Tšebelisano ena e matlafalitsoe ho theha li-enzyme inhibitors, li-receptor ligands, le lisebelisoa tse ling tsa meriana.Ka mohlala, boronic acid-based proteasome inhibitors e 'nile ea ntlafatsoa bakeng sa phekolo ea myeloma e mengata.Lefapeng la saense ea lisebelisoa, 4-Chlorophenylboronic acid e fumane ts'ebetsong ho fetoloa ha libaka kapa ho kopanya lisebelisoa tse sebetsang.Ka ho sebelisa sehlopha sa boronic acid, e ka etsa li-complexes tse matla tse fetolehang tse nang le polyols kapa metsoako e nang le hydroxyl.Thepa ena e ka sebelisoa hampe bakeng sa ts'ebetso ea holim'a metsi, joalo ka ho etsa litlolo tse arabelang ka matla kapa ho lokisoa ha li-sensor bakeng sa ho bona lik'habohaedreite kapa li-analyte tse ling. , le mahlale a thepa.Reactivity ea eona ka carbon-carbon bond bond, bokhoni ba kenyelletso ea sehlopha se sebetsang, le bokhoni ba ho theha li-covalent bond tse ka khutlisang li etsa hore e be sesebelisoa sa bohlokoa ho bafuputsi ba mafapheng a sa tšoaneng a saense.