4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 E 'mala o mosehla ho ea ho amber ho ea phofo e tala e lefifi
| Nomoro ea lethathamo | XD90156 |
| Lebitso la Sehlahiswa | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Foromo ea limolek'hule | C8H7N3O2 |
| Boima ba Molek'hule | 177.16 |
| Lintlha tsa polokelo | Lebenkele ho RT |
Tlhaloso ea Sehlahisoa
| Ponahalo | Bosehla bo kganyang ho isa ho phofshoana e botala bo fifetseng ho isa ho kotola |
| Assay | ≥98.0% |
| Botenya | 1.433 |
| Sebaka se qhibilihang | 300 ºC |
| Ntho e belang | 633°C ho 760 mmHg |
| flash point | 336.7°C |
| Solubility | E qhibiliha ka ammonium hydroxide, sodium carbonate kapa setsi se seng. |
1.Re ile ra hlahloba le ho bapisa phello ea li-antihistamine tse hlano tsa H1 ka ho phatloha ho hoholo ha oxidative ka tekanyo e eketsehileng le ea intracellular ea batho ba ka thōko le ba susumelitsoeng ke polymorphonuclear leukocyte. tatellano ea boemo ba potency bakeng sa H1-antihistamines ho fokotsa chemiluminescence e ile ea hlahlojoa extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine le sebakeng sa intracellular: loratadine> dithiaden.H1-antihistamine e fapana haholo ho ea ka sebopeho sa bona sa lik'hemik'hale ka bobeli ka bobeli ba lik'hemik'hale tse ling ha li ntse li le teng. - le sebaka sa intracellular sa li-neutrophils tse hlohlellelitsoeng tse ka thoko.
Litsamaiso tsa 2.Chemiluminescence tse matlafalitsoeng ke isoluminol kapa luminol hammoho le peroxidase ke mekhoa e hlokolosi ea ho lemoha mefuta ea oksijene e sebetsang (ROS) e hlahisoang ke phagocyte NADPH oxidase.Li-substrates tse peli tsa amplifying li tšoana haholo ka sebopeho, li fapana feela ka boemo ba sehlopha sa amino ka lesale la monko o monate oa limolek'hule.Phapang ena e etsa hore isoluminol e be molek'hule e fokolang ea lipophilic e ke keng ea kenella ka har'a lera la baeloji.Tšebeliso ea isoluminol ka hona e lekanyelitsoe lithutong tse sebetsanang le secretion ea oksijene metabolites.Thutong ena re bontša hore li-peptide tsa maiketsetso tse nkiloeng sebakeng sa N-terminal ea protheine ea annexin AI e laoloang ke calcium e kena-kenana le ho fumanoa ha li-radicals ka isoluminol-amplified, empa eseng tsamaisong ea luminol-amplified.Li-peptide tse nkiloeng ho annexin AI li fokotsa tlhahiso ea leseli ka isoluminol e hlasimolohileng ke superoxide le horseradish peroxidase (HRP) ka foryl-methionyl-leucyl-phenylalanine- le phorbol my ristate acetate-stimulated cells, hammoho le hydrogen peroxide le HRP.Mokhoa o nepahetseng oa ho thibela ha o tsejoe.Liphetho tse hlahisitsoeng li fana ka maikutlo a matla a hore karabelo e fokotsehileng ea cellular e fumanoeng ka isoluminol-amplified chemiluminescence e lokela ho netefatsoa ka mokhoa o mong oa ho tseba ho lokolloa ha superoxide anion le hydrogen peroxide.
