4-Amino-1-((2R,4S,5R) -4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one Cas:951-77-9
| Nomoro ea lethathamo: | XD90580 |
| Cas: | 951-77-9 |
| Foromo ea molek'hule: | C9H13N3O4 |
| Boima ba Molek'hule: | 227.22 |
| Boteng: | E teng thepeng e teng ka lebenkeleng |
| Theko: | |
| Sephutheloana: | 1g USD10 |
| Sephutheloana sa Bongata: | Kopa Quote |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu ea kristale |
| Tlhahlobo | 99% |
| Melting Point | 196°C -200°C |
Thymidine phosphorylase (TP, EC 2.4.2.4) e hlokometse sebopeho sa substrate e nang le boitsebiso bo phahameng, ka bobeli ba motheo le lihlopha tsa ribosyl.Ho nkeloa sebaka ha 3'-OH ea thymidine ho ile ha susumetsa haholo ts'ebetso ea eona ea matla le TP.Phetoho ea li-nucleosides tsa pyrimidine tse nang le likarolo tsa motheo tse fetotsoeng ho ea ho foromo e lumellanang le 1-phosphate e ne e fokola.Mosebetsi oa sehlopha sa ho tlohela o fokotsehile ka ho eketseha ha monko o monate oa pyrimidine base moiety, ka lebaka la bothata bo eketsehileng ba ho polarizing motheo ka li-amino acid sebakeng sa sebaka se sebetsang.Phetoho ea lihlopha tse sebetsang tsa 3' le 5' e ne e atisa ho fokotsa sekhahla sa karabelo le phesente ea phetoho le TP.Haholo-holo sehlopha sa ribosyl 3' hydroxyl se ne se le bohlokoa ka sebopeho bakeng sa ho tlama karolo e ka tlaase ke enzyme.Kinetic assay e bonts'itse ka ho hlaka boleng bo phahameng ba K(m) le boleng bo tlase ba V(max) mabapi le ho nkela sehlopha sa 3' hydroxyl sebaka ka hydrogen.
