Lihlahisoa

(3S) -3 - [(5-Bromo-2-chlorophenyl) methyl]phenoxy]tetrahydrofuran ke motsoako oa lik'hemik'hale o leng oa sehlopha sa lihlahisoa tsa tetrahydrofuran.E atisa ho sebelisoa tšimong ea lipatlisiso tsa meriana le nts'etsopele ka lebaka la thepa ea eona ea phekolo e ka 'nang ea e-ba teng.E' ngoe ea likopo tse ka sehloohong tsa motsoako ona ke bokhoni ba eona ba ho sebelisana le li-receptor tse fapa-fapaneng tsa likokoana-hloko, li-enzyme, kapa liprotheine 'meleng oa motho.Tšebelisano ena e ka lebisa ho feto-fetoha ha litsela tse khethehileng tsa lik'hemik'hale, tse ka 'nang tsa fella ka liphello tsa phekolo.Hangata bafuputsi ba hlahloba karolo ea motsoako e le motho ea ka khonang ho sebelisa lithethefatsi bakeng sa maloetse a sa tšoaneng. Likarolo tsa sebopeho sa motsoako, ho kenyelletsa le ho ba teng ha lesale la tetrahydrofuran le sehlopha sa phenyl se nkeloang sebaka, se tlatsetsa ho thepa ea eona e ikhethang ea meriana.Sehlopha sa phenyl se fana ka litšebelisano tsa hydrophobic, tse ka amang ho qhibiliha ha motsoako le kamano e tlamang ho lebisa liprotheine.Ho phaella moo, boteng ba liathomo tsa bromine le chlorine ka lesale la phenyl li eketsa ho feto-fetoha ha metsoako ea lik'hemik'hale tsa lik'hemik'hale, tse ka khonang ho lumella litšebelisano tse khethehileng le limolek'hule tsa likokoana-hloko tse lebisitsoeng. -Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran ho li-receptors tse khethehileng kapa li-enzyme li etsa qeto ea hore na e ka sebelisoa joang ka ho phekola.Ka lebaka leo, bafuputsi ba batlisisa liphello tsa eona linthong tse fapa-fapaneng tsa limolek'hule, tse kang li-receptor tse amehang ho ruruha, kankere, kapa mathata a tsamaiso ea methapo ea bohareng.Ho ka sebelisoa liteko tse fapaneng tsa baeloji le mefuta ea liphoofolo ho fumana mokhoa oa ts'ebetso ea eona, ho monya, ho ajoa, metabolism le ho ntšoa ha eona.Lintlha tsena li bohlokoa ho lekola pharmacokinetics ea motsoako le ho utloisisa hore na e sebelisana joang le 'mele oa motho.Leha ho le joalo, ke habohlokoa ho hlokomela hore (3S) -3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran e ntse e le boemong ba lipatlisiso, 'me mekhoa ea eona ea phekolo e ka' nang ea e-ba teng e ntse e tla hlahlojoa ka botlalo.Lithuto tse batsi, ho kenyeletsoa liteko tsa kliniki ho batho, li tla hlokahala ho fumana polokeho le katleho ea eona pele e ka nkuoa bakeng sa tšebeliso ea kalafo. Qetellong, (3S) -3-[4-[(5-Bromo-2-chlorophenyl) methyl) ]phenoxy]tetrahydrofuran hajoale e ntse e fuputsoa bakeng sa lits'ebetso tsa eona tsa kalafo tse ka bang teng lefapheng la lipatlisiso tsa meriana.Sebopeho sa eona se ikhethang sa lik'hemik'hale se kenya letsoho likamanong tsa eona tse ka bang teng le lipakane tse khethehileng tsa likokoana-hloko, ho bula menyetla bakeng sa nts'etsopele ea lisebelisoa tse ncha tsa phekolo.Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng le tlhahlobo ho fumana bokhoni ba eona ba 'nete e le motsoako oa phekolo.