Lihlahisoa

3-tert-Butoxycarbonylphenylboronic acid, eo hape e tsejoang e le Boc-phenylboronic acid, ke motsoako oa bohlokoa oa boronic acid o nang le lisebelisoa tsa bohlokoa ho organic synthesis le chemistry ea meriana. tlhaho.Sehlopha sa tert-butyloxycarbonyl (BOC) hangata se sebelisoa ho sireletsa nakoana lihlopha tse sebetsang tsa amine nakong ea maikutlo a fapaneng.Ka ho kopanya sehlopha sa BOC ho karolo ea amine, ts'ebetso ea amine e fokotsehile, e leng ho lumellang hore ho be le mekhoa e khethiloeng libakeng tse ling tsa molek'hule.Sehlopha sa BOC se ka tlosoa habonolo tlas'a maemo a bonolo, kahoo se senola ts'ebetso ea pele ea amine.Leano lena la lihlopha tse sireletsang le etsa hore ho be le motsoako o sebetsang hantle oa limolek'hule tse rarahaneng, tse kang meriana le lihlahisoa tsa tlhaho.Ho feta moo, 3-tert-Butoxycarbonylphenylboronic acid e sebetsa e le reagent ea bohlokoa bakeng sa ho thehoa ha carbon-carbon bond.Li-boronic acid, ho akarelletsa le Boc-phenylboronic acid, li etsa li-ester tsa boronate habonolo ha li arabela ka li-nucleophiles, tse kang joala kapa li-amine.Li-ester tsena tsa boronate li ka ba le liphetoho tse fapaneng, ho kenyelletsa le Suzuki-Miyaura cross-coupling reactions, Negishi couplings, le Stille couplings.Liphetoho tsena li etsa hore ho thehoe limolek'hule tse rarahaneng tse nang le mekhoa e fapaneng ea ho fetola le lihlopha tse sebetsang.Boc-phenylboronic acid e thusa ka ho khetheha bakeng sa ho hlahisa karolo ea phenylboronic acid ho limolek'hule tse lebisitsoeng.Ts'ebetso ea asiti ea boronic e ka sebelisana ka mokhoa o ikhethileng le li-diol kapa lihlopha tse sebetsang tsa boronate-sensitive ester ho sepheo sa baeloji, e nolofalletsang moralo oa li-inhibitors tsa enzyme tse thehiloeng ho boronate le li-receptor ligands.Boc-phenylboronic acid e ka kenyelletsoa ho li-inhibitors tsa molek'hule tse nyane, li-peptide, kapa li-prodrugs ho fana ka thepa e lakatsehang kapa ho ntlafatsa sepheo sa sepheo.Lik'hemik'hale tsena tse thehiloeng ho boronate li bontšitse tšepiso ea ho phekola maloetse a sa tšoaneng, ho akarelletsa le kankere, lefu la tsoekere le ho ruruha.Ka kakaretso, 3-tert-Butoxycarbonylphenylboronic acid, kapa Boc-phenylboronic acid, e fumana mekhoa e sa tšoaneng ea ho sebelisa metsoako ea tlhaho le lik'hemik'hale tsa meriana.Sehlopha sa eona sa BOC se sebetsa e le sehlopha se sireletsang, se lumellang hore ho be le mekhoa e khethiloeng libakeng tse ling tsa molek'hule.Ho feta moo, ts'ebetso ea asiti ea boronic e thusa ho theha maqhama a carbon-carbon bond, e thusang ho kopanya limolek'hule tse rarahaneng tsa manyolo.Ho feta moo, Boc-phenylboronic acid e bapala karolo ea bohlokoa k'hemistri ea meriana, moo e sebelisoang ho rala li-inhibitors tsa enzyme tse thehiloeng ho boronate le li-receptor ligands.Ka kakaretso, Boc-phenylboronic acid ke reagent ea bohlokoa e thusang tsoelopeleng ea k'hemistri ea maiketsetso le lipatlisiso tsa sibollo ea lithethefatsi.