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Lihlahisoa

3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99%

Tlhaloso e Khutšoanyane:

Nomoro ea lethathamo: XD90062
Cas: 14933-08-5
Foromo ea molek'hule: C17H35NO5S
Boima ba Molek'hule: 335.55
Boteng: E teng thepeng e teng ka lebenkeleng
Theko:
Sephutheloana: 25g USD30
Sephutheloana sa Bongata: Kopa Quote

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Nomoro ea lethathamo XD90062
Lebitso la Sehlahiswa 3-(N,N-dimethyldodecylammonio) propanesulfonate
CAS 14933-08-5
Foromo ea limolek'hule C17H35NO5S
Boima ba Molek'hule 335.55
Lintlha tsa polokelo Ambient
Khoutu ea Lekhetho e Kopantsoeng 29239000

Tlhaloso ea Sehlahisoa

Ponahalo Phofo e tšoeu
Assay 99% mets
Mocheso oa polokelo +20 ° C

Liphello tsa li-detergents ho ts'ebetso ea P-glycoprotein atpase: liphapang tsa pherekano ea mesebetsi e itšetlehileng ka basal le verapamil.

P-glycoprotein (P-gp), membrane ea plasma glycoprotein e amanang le phenotype e hanyetsanang le lithethefatsi tse ngata, e ikarabella bakeng sa ho tsoa ha ATP-e itšetlehileng ka mefuta e sa tšoaneng ea li-amphiphilic.Re sebelisa li-membrane vesicles tse lokiselitsoeng ho tloha moleng oa lisele tse hanyetsanang le lithethefatsi tse ngata tsa DC-3F/ADX, re ithutile ho ferekanngoa ha basal (ke hore, ha ho se na lithethefatsi) le mesebetsi e itšetlehileng ka verapamil ea P-gp ATPase e susumetsoang ke li-detergent tse sa tšoaneng, ka ho se solubilizing, hammoho le ho solubilizing, concentrations.Ts'ebetso e tsoelang pele ea "membrane solubilization" e nang le "detergent concentration" e ntseng e eketseha e ile ea shejoa ka liteko tsa ho hasana ha leseli le centrifugation.Bakeng sa likhatiso tse sa qhibiliheng, li-detergents tsohle tse lekiloeng ntle le DOC li ile tsa etsa hore ho be le thibelo e itseng ea ts'ebetso ea P-gp ATPase, e neng e sa amahane le bongata ba lisebelisoa tse fapaneng tse lekiloeng tse kentsoeng lera.Tlhahlobo ea ts'ebetso ea P-gp e hlahisitsoeng ke verapamil e senola hore ts'ebetso ea P-gp ATPase e hlophisoa ka tsela e fapaneng ke li-detergents tse fapaneng maemong a sa solubilizing.Ka hona, litšebelisano tse khethehileng pakeng tsa P-gp le li-detergent li ka 'na tsa etsahala ho e-na le ho ferekanngoa ha lera la lefats'e.Ka mor'a ho qhibiliha ka lisebelisoa tse sa tšoaneng tse lekiloeng, mosebetsi oa basal P-gp ATPase o ne o thibetsoe ka ho feletseng, ntle le boteng ba CHAPS e ileng ea khona ho boloka mosebetsi ona ka tekanyo e lekanang le e lekantsoeng ka lera la matsoalloa.Leha ho le joalo, ts'ebetso ea P-gp ATPase e entsoeng ke verapamil e ile ea lahleha nakong ea P-gp solubilization ke CHAPS, empa e ile ea hlaphoheloa ka mor'a ho hlapolloa ha CHAPS ka tlas'a mahloriso a eona a bohlokoa a micellar.Maikutlo ana a bontša litšebelisano tse khethehileng pakeng tsa limolek'hule tsa P-gp le CHAPS ka har'a li-micelles tse tsoakiloeng.Ka kakaretso, lintlha tsa rona tse pakang litšebelisano tse khethehileng tsa P-gp / li-detergents li lumellana le sebaka sa libaka tsa ho tsamaisa lithethefatsi libakeng tsa P-gp transmembrane.


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    3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99%