Lihlahisoa

2-(Chloromethyl) -4-methylquinazoline ke motsoako oa lik'hemik'hale oa lelapa la quinazoline.Li-quinazoline ke metsoako ea tlhaho e nang le sebopeho sa bicyclic se entsoeng ka reng ea benzene e kopantsoeng le reng ea pyrimidine.Motsoako ona o khethehileng o na le matla a bohlokoa a ho sebelisoa lits'ebetsong tse fapa-fapaneng, ho kopanyelletsa le saense ea meriana le lisebelisoa. Sebaka se seng se seholo moo 2-(chloromethyl) -4-methylquinazoline e bontšitseng tšepiso e teng ka k'hemistri ea meriana.Li-derivatives tsa quinazoline li na le mefuta e fapaneng ea mesebetsi ea tlhaho, e etsang hore e khahle ho sibolloa le nts'etsopele ea lithethefatsi.Li 'nile tsa ithutoa ka bokhoni ba tsona ba ho phekola maloetse a sa tšoaneng, ho akarelletsa le kankere, mafu a methapo ea pelo le mafu a pelo.Ka lipatlisiso tsa kankere, metsoako e thehiloeng ho quinazoline e bontšitse liphello tse khahlanong le ho ata le ho thibela hlahala.Ka ho thibela litsela tse itseng kapa liprotheine tse lebisitsoeng tse amehang kholong ea lisele tsa mofetše le ho phela, li bonts'itse bokhoni e le lisebelisoa tsa kalafo tse sebetsang.Ho ba teng ha sehlopha sa chloromethyl ho 2-(chloromethyl) -4-methylquinazoline ho ka tsoela pele ho ntlafatsa katleho ea eona, kaha li-halogen substituents li bontšitsoe ho ntlafatsa bioactivity le khetho ea lithethefatsi. ea li-enzyme tse amehang mafung a neurodegenerative, joalo ka Alzheimer's le Parkinson's.Lik'hemik'hale tsena li bontšitse bokhoni ba ho tšela mokoallo oa mali-boko, e leng se etsang hore li khahle ka ho khetheha bakeng sa ho lebisa tlhokomelo ea tsamaiso ea methapo ea bohareng.Ntle le lits'ebetso tsa bona tsa meriana, quinazoline e boetse e fumane tšebeliso ea saense ea thepa.Sebopeho sa bona se ikhethang sa limolek'hule, hammoho le bokhoni ba bona ba ho fetola lik'hemik'hale tse fapa-fapaneng, li etsa hore e be li-blocks tsa ho haha ​​​​tse fapaneng bakeng sa ho kopanya lisebelisoa tse sebetsang.Lisebelisoa tsena li ka bonts'a thepa e kang fluorescence, electroconductivity, le ho lemoha limolek'hule, ho etsa hore e be molemo libakeng tse kang optoelectronics, sensing, le catalysis.The synthesis and modification of 2-(chloromethyl) -4-methylquinazoline e ka lokisoa ho fetola thepa ea eona bakeng sa ho khetheha. lits'ebetso.Liphetoho tse fapaneng tsa lik'hemik'hale, tse kang ho fetola, ho kenyelletsa, le ho kopanya, li ka sebelisoa ho hlahisa lihlopha tse sebetsang kapa ho fetola sebopeho sa mantlha.Ho feto-fetoha ha maemo hona ho lumella bafuputsi ho etsa le ho etsa lihlahisoa tse nang le thepa e ntlafetseng kapa mesebetsi e lebisitsoeng.Bioactivity ea eona, haholo lipatlisisong tsa mofetše le neuropharmacology, e e etsa mokhethoa ea khahlang bakeng sa nts'etsopele ea lithethefatsi.Ho feta moo, sebopeho sa eona se feto-fetohang se etsa hore e be moaho oa bohlokoa bakeng sa lisebelisoa tse sebetsang mafapheng a fapaneng.Ha lipatlisiso li ntse li tsoela pele, lipatlisiso tse ling li tla utulla bokhoni bo felletseng le ho sebetsa ha komporo ena likarolong tse fapaneng tsa mahlale le thekenoloji.