Lihlahisoa

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone, eo hape e tsejoang e le CF12, ke motsoako oa lik'hemik'hale o nang le ts'ebeliso e fapaneng lipatlisisong tsa meriana le motsoako.E' ngoe ea ts'ebeliso ea mantlha ea CF12 e ka karolo ea eona e le setsi sa moaho se feto-fetohang. kapa tse mahareng bakeng sa ho kopanya metsoako ea lintho tse phelang tse rarahaneng.CF12 e na le lihlopha tse sebetsang tse kang chloro le li-fluoro substituents, tse ka sebelisoang ho hlahisa lihlopha tse ling tse lakatsehang kapa liphetoho tsa sebopeho.Sena se lumella litsebi tsa k'hemistri ho Customize thepa ea motsoako le ho ntlafatsa litšobotsi tsa eona tsa pharmacological bakeng sa dikopo tse itseng.CF12 e bontšitse bokhoni ba ho nts'etsopele ea bonkgetheng ba lithethefatsi bakeng sa libaka tse ngata tsa phekolo.Mohlala, boteng ba chloro le fluoro substituents ho CF12 ho ka eketsa lipophilicity ea motsoako, e ka ntlafatsang bokhoni ba eona ba ho kenella lera la likokoana-hloko le ho ntlafatsa ho monya ha lithethefatsi.Thepa ena e lakatseha ka ho khetheha moralong oa meriana e tsamaisoang ka molomo.Ho feta moo, likarolo tsa sebopeho sa CF12 li etsa hore e be mokhethoa ea khahlisang bakeng sa ho hlahloba bokhoni ba eona e le moemeli oa antimicrobial.Motsoako oa motsoako oa li-halogen o bonts'itsoe hore o na le ts'ebetso e pharalletseng ea antimicrobial khahlano le mefuta e fapaneng ea libaktheria le li-fungus.Sena se bula menyetla ea hore CF12 e fuputsoe bakeng sa nts'etsopele ea li-antibiotics tse ncha kapa litlhare tse thibelang likokoana-hloko.Ho feta moo, CF12 e fumanoe e na le mesebetsi e itseng ea likokoana-hloko e etsang hore e be mokhethoa ea loketseng bakeng sa mekhoa e meng ea phekolo.Boithuto bo bontšitse hore CF12 e bonts'a thepa ea bohlokoa e khahlanong le ho ruruha, e ka etsang hore e be ea bohlokoa bakeng sa kalafo ea mafu a tšoauoang ke ho ruruha, joalo ka mafu a autoimmune kapa maemo a sa foleng. lipatlisiso le nts'etsopele lia hlokahala ho utloisisa ka botlalo bokhoni ba eona joalo ka mokhethoa oa lithethefatsi.Lithuto tse pharalletseng tsa preclinical, ho kenyeletsoa tlhahlobo ea in vitro le in vivo, lia hlokahala ho lekola katleho ea CF12, thepa ea pharmacokinetic, le boemo ba polokeho.Ho feta moo, ho ntlafatsa sebopeho sa lik'hemik'hale tsa CF12 le ho hlahloba ts'ebetso ea eona khahlanong le lipehelo tse khethehileng tsa lefu ho hlokahala ho notlolla bokhoni ba eona ba ho phekola ka botlalo. e na le ts'episo ea lipatlisiso tsa meriana le ho kopanya.Ho feto-fetoha ha eona e le mohaho oa mohaho ho lumella hore ho thehoe metsoako e rarahaneng ea lintho tse phelang, ha litšobotsi tsa eona tsa meriana tse kang lipophilicity le antimicrobial li etsa hore e be motho ea ka khonang ho ntlafatsa lithethefatsi libakeng tse kang lithibela-mafu, li-antifungal le li-anti-inflammatory agents.Leha ho le joalo, lipatlisiso tse batsi li ntse li hlokahala ho lekola ka botlalo bokhoni ba eona ba kalafo le ho tseba hore na e sebetsa joang joalo ka mokhethoa oa lithethefatsi.