Trimethoprim Cas: 738-70-5
| Nomoro ea lethathamo | XD92385 |
| Lebitso la Sehlahiswa | Trimethoprim |
| CAS | 738-70-5 |
| Foromo ea molek'hulela | C14H18N4O3 |
| Boima ba Molek'hule | 290.32 |
| Lintlha tsa polokelo | 2-8°C |
| Khoutu ea Lekhetho e Kopantsoeng | 29335995 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phoofolo e tšoeu kapa e mosehla o mosoeu |
| Assay | 99% mets |
| Melting Point | 199 - 203 Deg C |
| Litšepe tse boima | ≤20ppm |
| Tahlehelo ka ho Omisa | ≤1.0% |
| Lintho Tse Amanang | ≤0.2% |
| Solubility | E qhibiliha hanyenyane haholo ka metsing, e qhibiliha hanyenyane joala, hoo e batlang e sa qhibilihe ka ether |
Trimethoprim ke lipophilic le fokolang alkaline pyrimethamine sehlopha bacteriostatic agent.Ke phofo ea kristale e tšoeu kapa e batlang e le tšoeu, ha e na monko, e baba, 'me e qhibiliha hanyenyane ka chloroform, ethanol kapa acetone, empa e batla e sa qhibilihe ka metsing 'me e qhibiliha haholo ka tharollo ea glacial acetic acid.E na le antibacterial spectrum e tšoanang le lithethefatsi tsa sulfa, empa e na le phello e matla ea antibacterial.E na le phello e ntle ea ho phekola Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, le mefuta e meng ea libaktheria tse nang le gram-positive le tse mpe.Empa ha e sebetse khahlano le ts'oaetso ea Pseudomonas aeruginosa.Boikoetliso ba eona bo fokolang hangata bo ka tlase ho 10 mg/L ha tšebeliso e le 'ngoe e le bonolo ho baka khanyetso ea baktheria, kahoo hangata ha e sebelisoe e le mong,' me haholo-holo e kopantsoe le lithethefatsi tsa sulfa ho etsa litokisetso tsa motsoako bakeng sa phekolo ea meriana ea mafu a moroto, mala. tšoaetso, tšoaetso ea ho hema, letšollo, enteritis, feberu ea mala, meningitis, otitis media, meningitis, sepsis le tšoaetso ea lisele tse bonolo.E na le phello ea ho phekola typhoid le paratyphoid effect e seng ka tlase ho ampicillin;E ka boela ea kopanngoa le litlhare tsa sulfa tse sebetsang nako e telele bakeng sa ho thibela le ho phekola lefu la malaria la falciparum le hananang le meriana.
Molao-motheo oa antibacterial oa trimethoprim ke ho kena-kenana le metabolism ea folate ho baktheria.Mokhoa o ka sehloohong oa ts'ebetso ke thibelo e khethiloeng ea ts'ebetso ea dihydrofolate reductase ho libaktheria e le hore dihydrofolate e se ke ea fokotsoa ho tetrahydrofolate.Kaha motsoako oa folic acid ke karolo e ka sehloohong ea biosynthesis ea nucleic acid, ka hona sehlahisoa se thibela motsoako oa li-nucleic acid le liprotheine tsa baktheria.Ho feta moo, kamano e tlamang ea trimethoprim (TMP) ho bacterial dihydrofolate reductase enzyme e matla ka makhetlo a mahlano ho feta ho mammalian dihydrofolate reductase.Motsoako o pakeng tsa eona le lithethefatsi tsa sulfa o ka baka thibelo e 'meli ho folic acid biosynthesis metabolism ea baktheria e le hore ho be le phello ea synergistic e tla ntlafatsa ts'ebetso ea antibacterial ea lithethefatsi tsa sulfa,' me e ka fetola phello ea antibacterial ho phello ea bactericidal e fokotsang ho hanyetsa lithethefatsi. mathata.Ho phaella moo, sehlahisoa se ka boela sa ntlafatsa liphello tsa antibacterial tsa mefuta e mengata ea lithibela-mafu (tse kang tetracycline, gentamicin).
