Lihlahisoa

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) pyridin-3-yl)piperazine-1-carboxylate ke motsoako o nang le bokhoni bo boholo k'hemistri ea bongaka le nts'etsopele ea lithethefatsi.Sebopeho sa eona se rarahaneng sa limolek'hule se fana ka maikutlo a mefuta e fapaneng ea mekhoa e ka sebelisoang.Motsoako ona o na le piperazine-1-carboxylate core, e leng sekhahla se sebelisoang ka tloaelo k'hemistri ea meriana ka lebaka la tlhaho ea eona e fapaneng le mefuta e mengata ea menyetla ea sepheo sa lithethefatsi.Ho ba teng ha karolo ea piperazine ho lumella ho sebelisana le li-receptor tse fapa-fapaneng le li-enzyme, ho etsa hore e be mokhethoa ea thahasellisang bakeng sa nts'etsopele ea li-agent tsa phekolo. 8-dihydropyrido [2,3-d] pyrimidin-2-yl sehlopha ka sebopeho se fana ka ts'ebetso e ka bang teng ea pharmacological.Li-derivatives tse joalo tsa pyrido [2,3-d] pyrimidine li 'nile tsa ithutoa haholo bakeng sa thepa ea tsona e thibelang ho ruruha, e thibelang likokoana-hloko le ea kankere.Lihlopha tsa cyclopentyl le methyl li kenya letsoho ho lipophilicity ea motsoako, e ka ntlafatsang ho khoneha ha lisele tsa eona le bioavailability.Sehlopha sa tert-butyl ester se fana ka botsitso ho motsoako 'me se ka fetoloa habonolo ho lihlopha tse ling tse sebetsang, ho lumella hore ho be le liphetoho tse ling kapa ho tsoa ho tsona.Ho feto-fetoha ha maemo ho bohlokoa ho lik'hemik'hale tsa meriana, kaha ho etsa hore ho be le metsoako e matla le e khethiloeng.Sehlopha sa pyridin-3-yl sebopeho se sebetsa e le li-ligand tse ka bang teng bakeng sa li-receptor tse fapa-fapaneng, tse kang G protein-coupled receptors (GPCRs).Sena se fana ka maikutlo a hore motsoako o ka 'na oa e-ba le tšusumetso litseleng tsa lipontšo tsa intracellular 'me o ka hlahlojoa ka ho eketsehileng bakeng sa bokhoni ba oona e le modulator kapa mohanyetsi oa li-receptor tse itseng tse amehang maemong a mafu.Sebopeho sa kakaretso sa tert-butyl 4-(6-((6-) (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate lintlha-khōlō bokhoni ba eona ho nts'etsopele ea liphekolo tse ncha.E fana ka menyetla ea ho batlisisa thibelo ea enzyme, ho tlama li-receptor, le ho feto-fetoha ha mekhoa e sa tšoaneng ea likokoana-hloko.Likarolo tsa eona tse ikhethang tsa sebopeho le mesebetsi e ka bang teng ea baeloji li etsa hore e be motsoako o khahlisang bakeng sa lipatlisiso tse tsoelang pele le nts'etsopele lefapheng la k'hemistri ea bongaka.Qetellong, tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate e na le tšepiso e le motsoako o nang le mekhoa e mengata bakeng sa nts'etsopele ea lithethefatsi.Sebopeho sa eona se rarahaneng le mesebetsi e ka 'nang ea e-ba teng ea phekolo ea meriana e etsa hore e be mokhethoa ea thahasellisang bakeng sa lipatlisiso tse tsoelang pele e le moemeli oa phekolo bakeng sa maloetse le maemo a sa tšoaneng.