Lihlahisoa

Silver trifluoromethanesulfonate, eo hape e tsejoang e le AgOTf, ke sesebelisoa se matla le se feto-fetohang se sebelisoang liphetohong tse fapaneng tsa lik'hemik'hale.Ke ea sehlopha sa triflates tšepe, tse molemo haholo ka synthesis manyolo ka lebaka la Lewis acidity le bokhoni ba ho activate substrates.E 'ngoe ea dikopo senotlolo sa silevera trifluoromethanesulfonate ke e le catalyst ka karabelo manyolo.E ka thusa liphetoho tse fapaneng, ho kenyelletsa le karabelo ea carbon-carbon bond, joalo ka Friedel-Crafts alkylation and acylation reactions, hammoho le karabelo ea carbon-nitrogen bond, joalo ka N-acylation ea amines kapa synthesis ea amides.Sebopeho sa Lewis sa acidic sa AgOTf se e nolofalletsa ho hokahana le li-substrates tse ruileng tsa elektronike, tse lebisang ts'ebetsong ea lik'hemik'hale tse khethehileng le ho thusa karabelo e lakatsehang.Mosebetsi oa eona oa ho thusa ke oa bohlokoa ka ho khetheha ho kopanngoeng ha meriana, agrochemicals, le lik'hemik'hale tse ntle.AgOTf e boetse e na le thuso ho khothalletsang tlhophiso bocha le liketso tsa cyclization.E ka susumetsa maikutlo a fapaneng a ho hlophisa bocha, joalo ka Beckmann rearrangement, e fetolang li-oxime ho li-amide kapa li-ester, kapa ho hlophisoa bocha ha allic alcohols ho etsa metsoako ea carbonyl.Ho feta moo, e ka thusa karabelong ea libaesekele, e nolofalletsang ho thehoa ha metsoako ea cyclic e nang le litsamaiso tse rarahaneng tsa mehele.Sebopeho sa Lewis se nang le asiti sa AgOTf se phetha karolo ea bohlokoa liketsong tsena ka ho nolofatsa tlhophiso e hlokahalang ea bonto le mehato ea cyclization. Ho feta moo, silevera ea trifluoromethanesulfonate e sebelisoa ho kenya libonto tsa carbon-hydrogen (CH).E ka kenya tšebetsong li-bond tsa CH tse haufi le lihlopha tse sebetsang, joalo ka ts'ebetsong ea li-bond tse nkhang hamonate tsa CH kapa ts'ebetsong ea li-bond tsa alllic kapa tsa benzylic CH.Ts'ebetso ena e lumella ts'ebetso e latelang ea bond ea CH, e lebisang ho thehoeng ha li-bond tse ncha tsa carbon-carbon kapa carbon-heteroatom.Mokhoa ona, o tsejoang e le ts'ebetso ea CH, ke tšimo e ntseng e hōla ka potlako ho organic synthesis 'me e fana ka tsela e nepahetseng ea ho fihlella li-scaffolds tse rarahaneng tsa molek'hule.Ke habohlokoa ho hlokomela hore AgOTf e na le maikutlo a mongobo le moea, kahoo e lokela ho tšoaroa tlas'a maemo a laoloang.Hangata e sebelisoa ka bongata bo fokolang, joalo ka lipalo tsa catalytic, ka lebaka la ts'ebetso ea eona e phahameng.Tlhokomelo e lokela ho nkoa ho sebetsa sebakeng se nang le moea o motle le ho sireletsa reagent ho tloha ho pepesehela mongobo.Sebopeho sa eona sa Lewis acidic se e nolofalletsa ho kenya tšebetsong li-substrates, ho khothaletsa tlhophiso hape le karabelo ea cyclization, le ho kenya tšebetsong litlamo tsa CH, tse lebisang ho thehoeng ha limolek'hule tse rarahaneng tsa manyolo.Leha ho le joalo, ho tlameha ho nkuoe mehato ea ho itšireletsa ha ho sebetsoa le ho boloka AgOTf ho netefatsa botsitso ba eona le ho thibela maikutlo a sa batleheng.