Lihlahisoa

Nicotinamide Riboside e ka sebelisoa thutong ea bioloji ea liphatsa tsa lefutso tsa circadian reprogramming transcriptome sebeteng se bonts'itseng litsela tsa botsofali ho toeba.E boetse e eketsa NAD+ ka har'a cerebral cortex mme e fokotsa ho senyeha ha kelello mofuteng oa toeba oa transgenic oa lefu la Alzheimer's.

Nicotinamide adenine dinucleotide (NAD+) ke coenzyme ea bohlokoa eo, ha e fokotsoa ho NADH, e sebetsang e le ntho e fokotsang ho fana ka lielektrone bakeng sa phosphorylation ea oxidative le ATP synthesis ho mitochondria.NAD+ ke cofactor ea bohlokoa bakeng sa li-enzyme tse kang sirtuin, ADP-ribosyltransferases (ARTs), le Poly [ADP-ribose] polymerases (PARPs) 'me e lula e sebelisoa ke li-enzyme tsena.Tekanyo ea NAD +/NADH ke karolo ea bohlokoa ea boemo ba redox ea sele.(Verdin 2015).Ka lipalo tse ling, NAD kapa NADP e amanang le eona e nka karolo kotara ea karabelo eohle ea cellular (Opitz Heiland 2015).Ho na le likarolo tse arohaneng tsa NAD + khubung, mitochondria, le cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) e ka fetoloa NAD+ ka mohato o mahareng moo e fetoloang nicotinamide mononucleotide (NMN) ke NR kinase (Nrk) ebe NAD+ ke NMNATs.NR ka tlhaho e fumaneha lijong tse ling empa ka bongata bo tlase haholo (mohlala, mofuta o tlase oa micromolar).Ho tloha khale, NR e ne e le thata ho e fumana ka bongata bo hloekisitsoeng, empa ka lebaka la tsoelo-pele ea mekhoa ea ho kopanya (Yang 2007), ho tloha ka June 2013, e rekisoa e le tlatsetso ea lijo.