litaba

Neocuproine reagent ke reagent bakeng sa boikemisetso ba koporo, kristale e tšoeu kapa e mosehla-sootho, e halefisang.Haholo-holo e sebelisoa e le reagent bakeng sa boikemisetso ba cuprous, photometric boikemisetso ba koporo, boikemisetso ba ultra-micro mali tsoekere;organic synthesis.Neocuproine hydrochloride monohydrate e sebelisitsoe ho metha ho qhibiliha ha koporo ka li-alloys tsa Cu–Ni ho sebelisoa mokhoa oa colorimetric.E boetse e sebelisitsoe ho lokisa tharollo ea li-antioxidant ho lisampole tsa bioloji tse ipapisitseng le Cu reduction complexes.E ka sebelisoa e le selelekela sa ho lokisoa ha neocuproine, e sebelisoang e le sesebelisoa sa tlhahlobo bakeng sa qeto ea koporo ka lisampole tsa tikoloho ho sebelisoa mokhoa oa spectrophotometric.

Leha ho le joalo moriana o joalo o na le litšebeliso tse fapaneng haholo tsa bongaka.Haufinyane tjena, Eribulin e amohetsoe ho bapatsa ke National Medical Products Administration (NMPA) ea naha ea heso bakeng sa kalafo ea bakuli ba mofetše oa matsoele ba iphetang kapa ba metastatic ba fumaneng bonyane chemotherapy tse peli. mekhoa (ho kenyeletsoa li-anthracyclines le li-taxans) nakong e fetileng.E tlisitse mokhoa o mocha oa kalafo lefapheng la chemotherapy ea mofetše oa matsoele naheng ea China, hape e tlisa likhetho tse ling tsa kalafo bakeng sa bakuli.
Eribulin ke "non-taxane tubulin inhibitor".Ho fapana le taxane le vinblastine tubulin inhibitors, Eribulin e na le mokhoa o khethehileng oa ts'ebetso, o etsang hore Eribulin E ntse e sebetsa ho bakuli ka mor'a ho hanyetsa lithethefatsi ho yew;Eribulin e boetse e na le liphello tse se nang cytotoxic, ho kenyelletsa le ho tsosolosoa ha methapo ea mali, ho eketsa phallo ea lithethefatsi tse ling ka har'a tumor microenvironment, synergizing lithethefatsi tse ling, le ho fetola lisele tsa hlahala Phetoho ea epidermal-mesenchymal joalo-joalo.

Ho tloha ka kakaretso ea halichondrin B, tšebeliso ea li-reagents tse ncha tsa koporo e le li-intermediate, ho ea ho phetoho ea sebopeho sa Eribulin, ho ea ho tlhahiso ea indasteri ea Eribulin, bo-rasaense ba tsoang lithutong tsa thuto le lik'hamphani tsa meriana ba qetile lilemo tse fetang 20 tsa lipatlisiso.Lihlahisoa tsa tlhaho tse nkiloeng leoatleng li fetohile lithethefatsi tse ka phekolang kankere.Patlisiso le nts'etsopele ea Eribulin ke hobane reagent e ncha ea koporo ke ea bohlokoa haholo e le eona e bohareng ea API ea eona.Sesebelisoa se secha sa koporo se na le karolo e kholo e le setsi sa meriana le setsi sa ho hloekisa lisebelisoa tse phahameng.

Sebopeho sa limolek'hule tsa Eribulin se na le litsi tsa chiral tse 19, 'me mehato ea ho kopanya e bolelele ba mehato e 62.Ho fihlela joale, Eribulin e ntse e nkoa ke indasteri e le lithethefatsi tse rarahaneng ka ho fetisisa tse se nang peptide tse hlahisoang ke motsoako o hloekileng oa lik'hemik'hale, 'me e ka bitsoa Mount Everest indastering ea lik'hemik'hale tsa lik'hemik'hale.
Lethathamo le atlehileng la Eribulin le bonts'a bophahamo bo bocha boo lik'hamphani tsa meriana li ka li fihlelang ho kopantseng lik'hemik'hale le tlhahiso ea indasteri.E boetse e tlisa mehopolo e mengata ea tlhahlobo le kalafo le likhetho ho lingaka tsa China.Ho na le tšepo ea hore nakong e tlang ea boikoetliso, moriana o mocha oa chemotherapeutic Eribulin o ka tlisa tšepo e ncha ho bakuli ba mofetše oa matsoele.