Lihlahisoa

N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide ke motsoako oa lik'hemik'hale o ka sebelisoang lipatlisisong tsa meriana, haholo-holo ntlafatsong ea meriana e mecha.Sebopeho sa eona se ikhethang sa limolek'hule se nang le thiazolo[4,5-b]pyridine le benzamide moieties e fana ka menyetla ea ho sebelisa mefuta e fapaneng ea meriana.E 'ngoe ea litšebeliso tsa mantlha tsa N-(5-bromo-[1,3]thiazolo[4,5-b) ]pyridin-2-yl)benzamide e tšoana le pharmacophore, tšobotsi ea bohlokoa ea sebopeho e sebetsanang le lipakane tsa tlhaho 'meleng.Ho ba teng ha selikalikoe sa thiazolo [4,5-b] pyridine se lumella hore motsoako o etsoe e le li-ligand tse ka 'nang tsa e-ba teng' me li tlamahane le lipakane tse itseng, tse kang li-receptor kapa li-enzyme, tse amehang mekhoeng e sa tšoaneng ea mafu.Ka ho fetola li-substituents tsa lesale la thiazolo [4,5-b] pyridine kapa sehlopha sa benzamide, bo-rasaense ba ka fetola likamano tsa motsoako ho lebisa litsela tse itseng kapa maloetse.Motsoako ona o ka sebetsa e le qalo ea ho kopanya le ho ntlafatsa metsoako ea loto mananeong a ho sibolla lithethefatsi.Ho feta moo, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide. e ka sebelisoa lithutong tsa kamano ea tšebetso ea sebopeho (SAR).Ka ho kopanya li-derivatives le li-analogue tsa motsoako ona, bafuputsi ba ka lekola hore na liphetoho tse fapaneng li ama tšebetso ea eona ea tlhaho le matla a eona joang.Tlhahisoleseding ena ke ea bohlokoa moralong o utloahalang oa batho ba bacha ba nang le ts'ebetso e ntlafetseng le litla-morao tse fokotsehileng. yl) benzamide e ka fumana ts'ebeliso ho baeloji ea lik'hemik'hale le lithutong tsa boitsebahatso ba sepheo.E ka sebelisoa e le motsoako oa lisebelisoa litlhahlobong tsa baeloji ho hlakisa ts'ebetso ea lipheo le litsela tse ikhethileng lits'ebetsong tsa cellular.Ka ho ithuta liphello tsa motsoako ona tsamaisong ea lisele tsa cellular, bo-rasaense ba ka fumana lintlha tsa bohlokoa mabapi le mekhoa ea motheo ea mafu 'me ba ka khona ho khetholla lipakane tse ncha tsa phekolo.Ho feta moo, N-(5-bromo-[1,3]thiazolo[4,5-b) ]pyridin-2-yl)benzamide e ka sebelisoa lipatlisisong tsa k'hemistri ea bongaka bakeng sa nts'etsopele ea li-anticancer agents.Li-thiazolo [4,5-b] pyridine derivatives li bontšitse tšepiso ea ho thibela litsela tse sa tšoaneng tsa kankere, tse kang protheine kinases e amehang khōlong ea lisele le ho phela.Ka ho kenyelletsa phetolo ea bromine le sehlopha sa benzamide, matla a motsoako le khetho e le moemeli oa anticancer a ka hlahlojoa le ho ntlafatsoa ka ho eketsehileng. -2-yl)benzamide ke motsoako oa bohlokoa o nang le ts'ebeliso e ka bang teng lipatlisisong tsa meriana.Sebopeho sa eona se ikhethang se fana ka menyetla ea ho qapa le ho kopanya metsoako ea lead, lithuto tsa SAR, ho tsebahatsa sepheo, le nts'etsopele ea li-anticancer agents.Ho feto-fetoha ha metsoako le bokhoni ba ho sibolloa ha lithethefatsi ho totobatsa bohlokoa ba eona ho ntšetseng pele lefapha la k'hemistri ea bongaka le tlatsetso ea eona e ka bang teng ho nts'etsopele ea mehato e mecha ea kalafo.