Lihlahisoa

EAAT2 glutamate transporter, e ikarabella bakeng sa >90% ea ho kenngoa ha hippocampal glutamate.Leha EAAT2 e hlahisoa haholo ho li-astrocyte, ~10% ea limolek'hule tsa EAAT2 li fumaneha liteisheneng tsa axon.Leha ho na le boemo bo tlase ba polelo ea EAAT2 ho li-terminals tsa glutamatergic, ha lilae tsa hippocampal li kentsoe ka bongata bo tlase ba d-aspartate (e EAAT2 substrate), li-axon terminals li bokella d-aspartate kapele joalo ka astroglia.Sena se bolela ho se lumellane ho sa hlalosoang lipakeng tsa kabo ea protheine ea EAAT2 le ts'ebetso ea lipalangoang tsa EAAT2.Khopolo-taba e 'ngoe ke hore (1) ho fapanyetsana ha heteroexchange ea substrate e ka hare e nang le substrate e ka ntle e potlakile haholo ho feta ts'ebeliso ea marang-rang le (2) li-terminals li rata ho fapanyetsana ho fapaneng ka lebaka la maemo a holimo a ka hare a glutamate.Leha ho le joalo, hajoale ha ho tsejoe hore na heteroexchange le uptake li na le litefiso tse tšoanang kapa tse fapaneng.Ho rarolla bothata bona, re sebelisitse mokhoa o tsosolositsoeng ho bapisa litefiso tse amanang le lits'ebetso tse peli ho likhoto le litoeba.Ho ts'oaroa ha marang-rang ho ile ha utloahala ho le molemo ho liphetoho tse ka bang teng lera 'me ho ile ha hlohlelletsoa ke li-anion tse ka ntle tse kenang ka ntle tumellanong le boteng ba anion conductance e sa kopanngoeng.Ka ho sebelisa ea morao-rao, re boetse re bontša hore sekhahla sa heteroexchange se itšetlehile ka bokhoni ba lera.Ntle le moo, lintlha tsa rona li fana ka maikutlo a boteng ba ho lutla ha sodium ho EAAT2.Ka ho kenyelletsa liphuputso tse ncha mofuteng oa rona o fetileng oa ho nkela glutamate ke EAAT2, re bolela esale pele hore matla a matla a phapanyetsano a bakoa ke ho tlama ha motlakase oa boraro Na(+).Ho feta moo, liteko tsa rona ka bobeli le lipapiso li fana ka maikutlo a hore litefiso tse amanang tsa ho nkeloa holimo le heteroexchange li ka bapisoa ho EAAT2.