Heparin sodium Cas: 9041-08-1 e tšoeu kapa e batlang e le tšoeu, phofo ea hygroscopic
| Nomoro ea lethathamo | XD90184 |
| Lebitso la Sehlahiswa | Heparin sodium |
| CAS | 9041-08-1 |
| Foromo ea limolek'hule | C12H17NO20S3 |
| Boima ba Molek'hule | 591.45 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 30019091 |
Tlhaloso ea Sehlahisoa
| Ponahalo | e tšoeu kapa e batla e le tšoeu, phofo ea hygroscopic |
| Assay | 99% |
| Ho potoloha ho itseng | Thepa e omileng ha ea lokela ho ba ka tlase ho +50 ° |
| pH | 5.5 - 8.0 |
| Endotoxin ea baktheria | Ka tlase ho 0.01 IU ho Yuniti ea Machaba ea heparin |
| Mokelikeli o setseng | Ho ea ka mokhoa o tloaelehileng oa ka hare o nang le palo e phahameng ea sebaka, methanol, ethanol, acetone, 'me, ka lehlakoreng le leng, 0.3%, 0.5%, kapa ka tlaase ho moo. |
| Masalla a ho Ignition | 28.0%-41.0% |
| Sodium | 10.5% -13.5% (ntho e omisitsoeng) |
| Protheine | <0.5% (ntho e omisitsoeng) |
| Naetrojene | 1.3% -2.5% (ntho e omisitsoeng) |
| Litšila tsa Nucleotidic | 260nm <0.10 |
| Tšepe e boima | ≤ 30ppm |
| Ho hlaka le 'mala oa tharollo | Tharollo e lokela ho ba e hlakileng e se nang mebala;Tse kang turbidity, ultraviolet-visible spectrophotometry, boikemisetso ba ho monya ka bolelele ba 640 nm, e ke ke ea feta 0.018;Joalo ka 'mala, ha o bapisoa le mosehla o tloaelehileng oa colorimetric mokelikeli, o ke ke oa teba |
| Ntho e Amanang | Kakaretso ea dermatan sulfate le chondroitin sulphate: eseng ho feta nako ea tlhoro e ts'oanang ea chomatogram e fumanoeng ka tharollo ea litšupiso.Tšilafalo efe kapa efe: ha ho litlhōrō tse ling ntle le tlhōrō ka lebaka la determatan sulfate le chondroitin sulfate tse fumanoang. |
| anti-FXa/anti-FIIa | 0.9-1.1 |
| Chromatography ea metsi | Taolo ea tharollo ea sampole ho chromatogram, dermatan sulfate (bolelele ba tlhoro le heparin le dermatan sulfate) lipakeng tsa bophahamo ba phula ea tlhoro e ke ke ea ba ka tlase ho 1.3, e fumanoeng ka tharollo ea tlhahlobo e ts'oana ka nako ea ho boloka le sebopeho ho tlhoro ea mantlha ea chromatogram e fumanoeng ka tharollo ea litšupiso.Phapang e amanang le nako ea ho boloka nako ha ea lokela ho feta 5% |
| Boima ba molek'hule le kabo ea boima ba limolek'hule | Boima ka karolelano boima ba limolek'hule e lokela ho ba 15000 - 19000. Boima ba limolek'hule tse fetang 24000 tsa sehlopha ha lia lokela ho feta 20%, boima ba limolek'hule tsa 8000 - 16000 tsa boima ba limolek'hule tsa 24000 - 16000 tsa karo-karolelano ha lia lokela ho ba tlase. ho feta 1 |
| ho lahleheloa ke boima ba 'mele | ≤ 5.0% |
| Likokoana-hloko | Kakaretso ea palo ea aerobic e sebetsang: <10³cfu/g.Li-fungus/tomoso <10²cfu/g |
| anti-factor IIa | ≥180 IU/mg |
Heparin, letsoai la sodium ke polima ea heparin e hlahisang phello ea eona e kholo ea anticoagulant ka ho kenya antithrombin.Ts'ebetso ena e baka phetoho ea conformational ho ATIII mme e lumella ho eketseha ha maemo ho loop ea sebaka sa eona se sebetsang.Heparin ke glycosaminoglycan e nang le sulfated haholo e tsejoang ka ho thibela ho ruruha.Heparin, Sodium Letsoai hape ke activator ea RyR le ATIII.
Lintho tsa 'mele le tsa lik'hemik'hale: Heparin sodium ke phofo e tšoeu kapa e batla e le tšoeu, ha e na monko, e na le hygroscopic, e qhibiliha ka metsing, ha e qhibilihe ka har'a metsoako ea lintho tse phelang tse kang ethanol le acetone.E na le tefiso e matla e mpe ka tharollo ea metsi 'me e ka kopana le li-cations tse ling ho theha limolek'hule tsa limolek'hule.Litharollo tsa metsi li tsitsitse haholoanyane ho pH 7.
Anticoagulant: Heparin sodium ke anticoagulant, mucopolysaccharide, letsoai la sodium la glucosamine sulfate le ntšitsoeng ho mucosa ea mala ea likolobe, likhomo le linku, 'me e ntšoa ke lisele tsa mast' meleng oa motho.'Me ka tlhaho e teng maling.Heparin sodium e na le mesebetsi ea ho thibela ho bokellana ha liplatelete le ho senya, ho thibela phetoho ea fibrinogen ho fibrin monomer, ho thibela sebopeho sa thromboplastin le ho hanyetsa thromboplastin e entsoeng, ho thibela phetoho ea prothrombin ho thrombin le antithrombin.Heparin sodium e ka lieha kapa ea thibela tšollo ea mali ka in vitro le in vivo.Mokhoa oa eona oa ts'ebetso o rarahane haholo mme o ama likhokahano tse ngata ts'ebetsong ea coagulation.Mesebetsi ea eona ke: ① thibela ho thehoa le ho sebetsa ha thromboplastin, kahoo e thibela prothrombin ho fetoha thrombin;② maemong a holimo, e na le phello ea ho thibela thrombin le lintlha tse ling tsa coagulation, ho thibela fibrinogen ho fetoha protheine ea fibrin;③ e ka thibela ho bokellana le ho senngoa ha liplatelete.Ho phaella moo, phello ea anticoagulant ea sodium ea heparin e ntse e amana le sulfate e matla ea sulfate ka molek'hule ea eona.Lintho tsa alkaline tse qosoang hantle joalo ka protamine kapa toluidine blue li ka fokotsa tefiso ea eona e mpe, kahoo e ka thibela anticoagulation ea eona.phello.Hobane heparin e ka kenya tšebetsong le ho lokolla lipoprotein lipase ka har'a vivo, hydrolyze triglyceride le low-density lipoprotein ea chylomicrons, kahoo e boetse e na le phello ea hypolipidemic.Heparin sodium e ka sebelisoa ho phekola lefu le matla la thromboembolic, disseminated intravascular coagulation (DIC).Lilemong tsa morao tjena, ho fumanoe hore heparin e na le phello ea ho tlosa lipids tsa mali.Ente e kenang ka methapo kapa ente e tebileng ea mesifa (kapa ente e ka tlas'a letlalo), li-unit tse 5,000 ho isa ho tse 10,000 nako le nako.Heparin sodium ha e na chefo e nyane mme tšekamelo ea ho tsoa mali ka tšohanyetso ke kotsi ea bohlokoa ka ho fetesisa ea heparin.E sa sebetse ka molomo, e tlameha ho tsamaisoa ka ente.Ente ea intramuscular kapa subcutaneous injection e halefisa haholo, ka linako tse ling ho ka 'na ha e-ba le maikutlo a ho kula,' me ho feta tekano ho ka ba ha baka ho tšoaroa ke pelo;ka linako tse ling ho lahleheloa ke moriri le lets'ollo.Ho phaella moo, e ntse e ka baka ho robeha ho sa tloaelehang.Tšebeliso ea nako e telele ka linako tse ling e ka baka thrombosis, e ka bang phello ea ho fokotseha ha anticoagulase-III.Heparin sodium e hanyetsanoa ho bakuli ba nang le tšekamelo ea ho tsoa mali, sebete se matla le ho se sebetse hantle ha renal, khatello e matla ea mali, hemophilia, intracranial hemorrhage, peptic ulcer, basali ba bakhachane le ka mor'a ho pepa, lihlahala tsa visceral, ts'oaetso le ho buuoa.
Lisebelisoa: Patlisiso ea biochemical, e sebelisetsoang ho thibela phetoho ea prothrombin ho thrombin, e nang le phello ea antithrombotic.
Lisebelisoa: Heparin sodium ke moriana oa biochemical oa mucopolysaccharide o ntšitsoeng ho porcine intestinal mucosa e nang le ts'ebetso e matla ea anticoagulant.Mclcan o ile a sibolla femoral mucopolysaccharide heparin ka har'a lisele tsa sebete ho tsoa ho lintja ha a ntse a ithuta mokhoa oa ho koala mali.Brinkous et al.e bontšitse hore heparin e na le ts'ebetso ea anticoagulant.Kamora hore heparin e sebelisoe joalo ka anticoagulant lits'ebetsong tsa bongaka ka lekhetlo la pele, e fumane tlhokomelo ho tsoa lefats'eng lohle.Leha e na le nalane ea lilemo tse fetang 60 ts'ebelisong ea bongaka, ha ho na sehlahisoa se ka e nkelang sebaka ka botlalo ho fihlela joale, ka hona e ntse e le e 'ngoe ea lithethefatsi tsa bohlokoa ka ho fetisisa tsa anticoagulant le antithrombotic biochemical.E na le mefuta e mengata ea tšebeliso ea meriana.E sebelisoa ho phekola infarction e matla ea myocardial le lefu la sebete la pathogenic.E ka sebelisoa hammoho le ribonucleic acid ho eketsa katleho ea lefu la sebete la mofuta oa B. E ka sebelisoa hammoho le chemotherapy ho thibela thrombosis.E ka fokotsa lipids ea mali le ho ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung.e boetse e na le phello e itseng.Heparin sodium e tlase ea boima ba molek'hule e na le ts'ebetso ea anticoagulant factor Xa.Boithuto ba Pharmacodynamic bo bonts'itse hore heparin sodium e tlase ea boima ba limolek'hule e na le phello e thibelang ho thehoa ha thrombus le arteriovenous thrombosis ka vivo le in vitro, empa e na le phello e fokolang ho coagulation le tsamaiso ea fibrinolysis, e bakang phello ea antithrombotic.ho tsoa mali ha ho ka etsahala.Heparin e sa qhekelloang ke motsoako oa li-amino glucan glycosides tse fapaneng tse ka liehisang kapa tsa thibela tšollo ea mali ka har'a vitro le vivo.Mokhoa oa eona oa anticoagulation o rarahane, 'me o na le phello likarolong tsohle tsa coagulation.Ho kenyelletsa ho thibela prothrombin ho thrombin;ho thibela mosebetsi oa thrombin;thibela phetoho ea fibrinogen ho fibrin;thibela ho bokellana ha platelet le ho timetsoa.Heparin e ntse e ka fokotsa lipids ea mali, ea theola LDL le VLDL, ea eketsa HDL, ea fetola ponahalo ea mali, ea sireletsa lisele tsa methapo ea mali, ea thibela atherosclerosis, ea khothalletsa phallo ea mali, le ho ntlafatsa phallo ea mali.
Lisebelisoa: Patlisiso ea biochemical, ho thibela phetoho ea prothrombin ho thrombin.
Litšebeliso: E sebelisoa ho lieha le ho thibela ho hoama ha mali
