Gentamycin Sulfate CAS: 1405-41-0 Phofo e tšoeu
| Nomoro ea lethathamo | XD90364 |
| Lebitso la Sehlahiswa | Gentamycin sulfate |
| CAS | 1405-41-0 |
| Foromo ea limolek'hule | C21H43N5O7H2So4 |
| Boima ba Molek'hule | 575.68 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
| Metsi | 15% max |
| pH | 3.5-5.5 |
| Tlhahlobo | 590IU/mg mets |
| Ho potoloha ho itseng | +107° ho ea ho +121° |
| Ponahalo | Phofo e tšoeu |
| Sulfate (SO4) | 32 - 35% |
| Molora o sulfated | <1.0% |
Kotsi ea mokokotlo ea mokokotlo e thatafalloa ke ho lieha ho lahleheloa ke li-oligodendrocyte, ho fella ka ho fokotseha ho sa feleng ho tsoelang pele.Ka hona, mekhoa ea ho fetisetsa li-transplantation ho fana ka lisele tsa leloko la oligodendrocyte le ho ntlafatsa boholo ba myelination ho bonahala eka ho nepahetse bakeng sa ho lokisoa ha mokokotlo oa mokokotlo.Phuputso ea hona joale e ile ea batlisisa hore na ho fetisoa ha lisele tsa "neural stem" tsa motho (NSCs) ho fetotsoe ka liphatsa tsa lefutso ho hlalosa Olig2 transcript factor, e leng molaoli oa bohlokoa oa tsoelo-pele ea oligodendrocyte, e ka ntlafatsa ho hlaphoheloa ha locomotor le ho ntlafatsa myelination ka rat contusive lesapo la lesapo la mokokotlo mohlala.HB1.F3 (F3) ) Mohala oa NSC oa motho ea sa shoeng o ile oa fetisoa ka vector ea retroviral encoding Olig2, molaoli oa bohlokoa oa nts'etsopele ea oligodendrocyte.Ho feteletsa ha Olig2 ho li-NSC tsa batho (F3.Olig2) ho ile ha etsa hore ho sebelisoe NKX2.2 le ho laola ho khetholla ha li-NSC ho li-oligodendrocyte lineage cell in vitro.Kenyelletso ea Olig2 e fane ka ts'ebetso e phahameng ea ho ata, 'me palo e kholoanyane ea F3.Olig2 NSCs e ile ea fumanoa ka libeke tsa 7 ka mor'a hore ho fetisetsoe mokokotlong oa mokokotlo ho feta oa F3 NSCs ea batsoali.Li-NSC tsa F3.Olig2 li ne li bontša ho falla khafetsa ho ea sebakeng se sesoeu, athe li-NSC tsa F3 hangata li ne li le ka har'a lintho tse bohlooho kapa ho potoloha le masoba.Boholo ba li-NSC tsa F3.Olig2 tse nang le taba e tšoeu e bolokiloeng e arotsoe ka li-oligodendrocyte tse hōlileng tsebong.Transplantation ea F3.Olig2 NSCs e ile ea eketsa boholo ba taba e tšoeu e bolokiloeng 'me ea fokotsa molumo oa cavity.Ho feta moo, li-grafts tsa F3.Olig2 li ile tsa eketsa haholo botenya ba sheath ea myelin ho pota-pota li-axon tabeng e tšoeu e bolokiloeng.Qetellong, liphoofolo tse nang le li-grafts tsa F3.Olig2 li bontšitse ntlafatso ea boleng ba li-hindlimbs locomotion.Ho fetisetsa li-NSC tse fetotsoeng ka liphatsa tsa lefutso ho arola leloko la oligodendrocytic e ka 'na ea e-ba leano le sebetsang la ho ntlafatsa liphello tse sebetsang ka mor'a ts'oaetso ea mokokotlo oa mokokotlo.Boithuto ba hajoale bo fana ka maikutlo a hore lintlha tsa limolek'hule tse laolang liqeto tsa bokamoso ba lisele li ka sebelisoa ho ntlafatsa bokhoni ba pheko ea kalafo e thehiloeng liseleng.
