Furazolidone Cas: 67-45-8
| Nomoro ea lethathamo | XD91885 |
| Lebitso la Sehlahiswa | "Furazolidone" |
| CAS | 67-45-8 |
| Foromo ea molek'hulela | C8H7N3O5 |
| Boima ba Molek'hule | 225.16 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e mosehla |
| Assay | 99% mets |
| Sebaka se qhibilihang | 254-256°C (Dec.) |
| Ntho e belang | 366.66°C (khakanyo e boima) |
| tekano | 1.5406 (khakanyo e fosahetseng) |
| index ea refractive | 1.7180 (khakanyo) |
| Fp | 2 °C |
| ho qhibiliha | asiti ea formic: soluble50mg/mL |
| pka | -1.98±0.20(E boletsoeng esale pele) |
| E hloahloa | Khanya e Kutloha |
| λmax | 365nm(DMSO)(lit.) |
| Botsitso | E tsitsitseng.E tukang.Ha e lumellane le lisebelisoa tse matla tsa oxidizing. |
The antibacterial spectrum ea furazolidone e tšoana le ea furazolidone.E le sethethefatsi se khahlanong le tšoaetso, se sebetsa hantle ho phekola Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, le Staphylococcus aureus.Libaktheria ha ho bonolo ho ba le khanyetso ea lithethefatsi sethethefatsi sena.Hape ha e na ho hanyetsana le lithibela-mafu tsa sehlopha sa sulfa.E sebelisoa haholo-holo bakeng sa phekolo ea meriana ea letšollo, enteritis, typhoid, paratyphoid le phekolo ea li-topical tsa trichomoniasis ea botšehali.
2. Sehlahisoa ke fungicide e nang le antibacterial spectrum e pharaletseng.E le sethethefatsi se thibelang tšoaetso, se sebetsa hantle bakeng sa ho alafa mefuta e fapaneng ea libaktheria tsa Gram-positive le tse mpe ho kenyelletsa Escherichia coli, Bacillus anthracis, le Paratyphoid bacilli.Ha e sebetse feela kalafong ea lets'ollo, enteritis, empa hape e sebelisoa ho phekola mafu a ka botšehaling.Lilemong tsa morao tjena, e na le ts'ebetso e ntle ea ho phekola feberu ea mala.E le tlatsetso bakeng sa lithethefatsi le lino tsa liphoofolo, e na le phello e ikhethang ea antibacterial ho Salmonella, Escherichia coli le Salmonella pullorum hape e na le phello e itseng ea thibelo ho protozoa (libaktheria tsa coccidia, joalo-joalo) 'me e etsa hore li se ke tsa fetoha habonolo ho hanyetsa lithethefatsi.Palo e nyane ea furazolidone e 'nile ea sebelisoa bakeng sa lits'ebetso tse ling (joalo ka pente e qhibilihang ka metsi le makhasi a pampiri) joalo ka li-fungicides.
3. Ke sethethefatsi se thibelang tšoaetso se sebelisetsoang ho thibela tšoaetso ea mala.
4. Furazolidone, e le fungicide, e na le mefuta e mengata ea antibacterial spectrum.Libaktheria tse hlaselehang habonolo ke Escherichia coli, Bacillus anthracis, paratyphoid rod, Shigella, le Klebsiella pneumoniae.Salmonella typhi le eona e na le kutloelo-bohloko ho eona.E sebelisoa haholo bakeng sa ho alafa mafu a bakoang ke letšollo, enteritis le k'holera.E ka boela ea sebelisoa bakeng sa ho phekola typhoid, paratyphoid, giardiasis le trichomoniasis.Motsoako le lithethefatsi tse khahlanong le asiti li ka sebelisoa bakeng sa ho phekola ho ruruha ha gastric ho bakoang ke Helicobacter pylori.Thepa: phofo e mosehla kapa phofo ea kristale, ha e na monko, ha e na tatso ea pele, ebe e baba hanyane;qhibiliha hanyenyane haholo ka metsing le ethanol;E qhibiliha hanyenyane ka chloroform 'me ha e qhibilihe ka har'a ether, e qhibiliha ka dimethylformamide le nitromethane.Mp: 255 ho 259 °C.Bola nakong ea ho qhibiliha.
Furazolidone e sebelisoa ho mafu a ka mpeng le vaginitis.E sebelisoa haholo-holo linaheng tse tsoelang pele ho phekola mafu a letšollo a mefuta e fapaneng ea etiology, empa ha se moriana oa khetho haeba ho na le pathogen e itseng e fumanoeng.Ho 'nile ha buelloa hore e sebelisoe e le moemeli oa bobeli ho giardiasis 'me e le karolo ea mefuta e mengata ea meriana ea tšoaetso ea Helicobacter.
3 - [(5-Nitrofurylidene) amino] -2-oxazolidinone (Furoxone) e hlaha e le phofo e tšehla ea kristale e nang le tatso e bohloko.Ha e qhibilihe ka metsing kapa joala.Furazolidone e na le ts'ebetso ea bactericidal khahlano le mefuta e batlang e batsi ea likokoana-hloko tsa mala, ho kenyelletsa S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, le Vibrio cholerae. E boetse e sebetsa khahlanong le protozoan Giardia lamblia.E buelloa bakeng sa kalafo ea molomo ea baktheria kapa letšollo la protozoal le bakoang ke likokoana-hloko tse hlaselehang habonolo.Tekanyetso e tloaelehileng ea batho ba baholo ke 100 mg makhetlo a 4 ka letsatsi.
Ke karoloana e nyane feela ea tekanyo e tsamaisoang ka molomo ea furazolidoneis e monyelitsoeng.Hoo e ka bang karolo ea 5 lekholong ea tekanyo ea molomo e fumanoa ka har'a moroto ka mokhoa oa metabolites tse 'maloa.Matšoenyeho a mang a ka mpeng a tlalehiloe ka tšebeliso ea ona. Joala bo lokela ho qojoa ha furazolidone e sebelisoahobane sethethefatsi se ka thibela aldehyde dehydrogenase.
