Lihlahisoa

Flucytosine, e tsejoang hape e le 5-fluorocytosine kapa 5-FC, ke moriana oa maiketsetso oa antifungal o sebelisoang haholo ho phekola mafu a fungal.E khetholloa e le antimetabolite, e bolelang hore e kena-kenana le mekhoa e tloaelehileng ea metabolism ea lisele tsa fungal, e lebisang ho thibelo ea bona kapa lefu.Flucytosine hangata e laolwa hammoho le mahlahana a mang a antifungal bakeng sa ts'ebetso e nepahetseng.E 'ngoe ea litšebeliso tsa bohlokoa tsa flucytosine ke ho phekola mafu a fungal a hlaselang, haholo-holo a bakoang ke mofuta oa Candida le Cryptococcus.Hangata e sebelisoa hammoho le moemeli e mong oa antifungal, joalo ka amphotericin B kapa fluconazole, ho ntlafatsa ts'ebetso ea eona ea antifungal.Flucytosine e sebetsa ka ho kena liseleng tsa fungal le ho fetoha 5-fluorouracil, e leng cytotoxic antimetabolite.5-fluorouracil joale e kena-kenana le motsoako oa fungal RNA le DNA, kahoo e thibela kholo ea fungal le ho ikatisa.Mokhoa ona oa synergistic o thusa ho loantša mefuta e mengata ea likokoana-hloko tsa fungal le ho eketsa katleho ea phekolo.Tšebeliso e 'ngoe ea bohlokoa ea flucytosine ke ho phekola Cryptococcus neoformans meningitis, tšoaetso e ka 'nang ea beha bophelo kotsing e amang lera le pota-potileng boko le lesapo la mokokotlo.Flucytosine e nkoa e le e 'ngoe ea litlhare tsa pele tse kopantsoeng le amphotericin B bakeng sa phekolo ea boemo bona.Therapy e kopantseng e thusa ho hlola mefokolo ea moriana o mong le o mong le ho fihlela litekanyetso tse phahameng tsa kalafo.Flucytosine e fihla maemong a lekaneng ka mokelikeli oa cerebrospinal, e lumella hore e atlehe ho lebisa tlhokomelo ea tšoaetso ea fungal tsamaisong ea methapo e bohareng.Flucytosine e ka boela ea sebelisoa bakeng sa phekolo ea mafu a mang a fungal, a kang tšoaetso e bakoang ke mefuta e itseng ea Candida le Aspergillus.Leha ho le joalo, tšebeliso ea eona e ka fokotsoa ka lebaka la kotsi ea ho ba le khanyetso, kaha fungus e ka fumana liphetoho tse etsang hore e se ke ea hlaseloa ke lithethefatsi.Tlhokomelo e haufi le tlhahlobo ea nako le nako ea karabo ea phekolo ke ea bohlokoa ha u sebelisa flucytosine ho netefatsa liphello tse nepahetseng tsa phekolo.Le hoja flucytosine ka kakaretso e mamelloa hantle, e ka ba le liphello tse ling tse mpe.Litla-morao tse tloaelehileng li kenyelletsa tšitiso ea mala, joalo ka ho nyekeloa ke pelo, ho hlatsa le letšollo.Hape ho ka baka khatello ea 'mele oa masapo, e leng se ka etsang hore tlhahiso ea lisele tsa mali e fokotsehe.Hangata liteko tsa mali li etsoa ho shebella palo ea lisele tsa mali nakong ea phekolo.Ka kakaretso, flucytosine ke meriana e thibelang likokoana-hloko e sebelisoang kalafo e kopanetsoeng bakeng sa phekolo ea mafu a fungal, haholo-holo a bakoang ke Candida le Cryptococcus mefuta.E sebetsa ka ho kena-kenana le fungal nucleic acid synthesis, e thibelang kholo ea bona le ho ikatisa.Flucytosine hangata e sebelisoa hammoho le li-antifungal tse ling 'me e bohlokoa haholo kalafong ea Cryptococcus neoformans meningitis.Leha ho le joalo, tšebeliso ea eona e hloka tlhokomelo e hlokolosi ka lebaka la kotsi ea ho hanyetsa le liphello tse mpe tse ka bang teng.