Lihlahisoa

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ke motsoako oa lik'hemik'hale o fumanang ts'ebetso lefapheng la k'hemistri ea meriana le nts'etsopele ea lithethefatsi.Sebopeho sa eona sa molek'hule se na le lesale la pyrrolidine le sehlopha sa tert-butyl sebakeng sa cis, sehlopha sa ethyl, le lihlopha tse peli tsa carboxylate.Motsoako ona ka tloaelo o fumanoa ka mokhoa oa letsoai la hydrochloride. E 'ngoe ea litšebeliso tse ka sehloohong tsa cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride e ka har'a motsoako le nts'etsopele ea lithethefatsi tse lebisitseng bohareng. tsamaiso ea methapo (CNS).Ho ba teng ha lesale la pyrrolidine, hammoho le lihlopha tsa tert-butyl le ethyl, li fana ka motsoako ona ka thepa e ka 'nang ea e-ba le neuroactive.Bafuputsi ba ka sebelisa motsoako ona e le sesebelisoa sa ho qala ho kopanya li-analogues kapa li-derivatives tse ka khethang ho sebelisana le li-receptor tse itseng kapa li-enzyme ho CNS.Ka ho fetola sebopeho le li-substitute, li ka ntlafatsa thepa ea pharmacokinetic ea motsoako, ho ntlafatsa kamano ea eona ea ho amohela, le ho ntlafatsa bokhoni ba eona ba phekolo.Ho feta moo, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride e ka ba e sebelisoa e le sesebelisoa lithutong tsa baeloji ho batlisisa karolo ea li-receptor kapa li-enzyme tse itseng lits'ebetsong tsa methapo.Ka ho sebelisa motsoako ona e le ligand kapa probe, bafuputsi ba ka ithuta kamano e tlamang, khetho le mokhoa oa ketso oa li-receptor kapa li-enzyme.Tlhahisoleseding ena ke ea bohlokoa bakeng sa ho utloisisa motheo oa limolek'hule oa mekhoa ea methapo ea meriana le bakeng sa nts'etsopele ea mekhoa e mecha ea phekolo e lebisitseng mafu a neurodegenerative, maemo a kelello, kapa mafu a methapo.E ka kenyelletsoa lilaebraring tsa metsoako, e hlahlojoang khahlanong le lipheo tse fapa-fapaneng, tse kang li-receptor kapa li-enzyme, ho khetholla metsoako e ka bang teng ea lead kapa batho ba ka sebelisang lithethefatsi.Tlhahlobo ena e lumella ho khetholla metsoako e bontšang thepa e lakatsehang ea phekolo ea meriana kapa liphello tse ka 'nang tsa e-ba teng tsa phekolo.Ho feta moo, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride e ka fumana thuso ho nts'etsopele ea lithethefatsi.Lithethefatsi ke metsoako e sa sebetseng kapa e sa sebetseng haholo e etselitsoeng ho kenngoa ka har'a sebopeho sa eona se sebetsang hang ka har'a 'mele.Ka ho fetola sebopeho sa motsoako ona, bafuputsi ba ka etsa mefuta ea lihlahisoa tse tsitsitseng haholoanyane, tse ntlafetseng tsa bioavailability, kapa tse ka tšelang lera la likokoana-hloko habonolo.Ka kakaretso, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ke motsoako o nang le ts'ebeliso e ka bang teng ho nts'etsopele ea lithethefatsi tse lebisitsoeng ho CNS. , e le motsoako oa lisebelisoa bakeng sa lithuto tsa baeloji, ho sibolloa ha lithethefatsi, le ho nts'etsopele ea lihlahisoa.Sebopeho sa eona se ikhethang sa limolek'hule se fana ka menyetla ea ho fetoloa le ho ntlafatsa ho ntlafatsa thepa ea eona ea meriana le mesebetsi ea tlhaho.Ho feto-fetoha ha maemo le bokhoni ba motsoako ona ho etsa hore e be letlotlo la bohlokoa lefapheng la k'hemistri ea meriana le nts'etsopele ea lithethefatsi.