Lihlahisoa

Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ke motsoako oa lik'hemik'hale o atisang ho sebelisoa lipatlisisong tsa meriana le nts'etsopele ea lithethefatsi.Sebopeho sa eona sa molek'hule se na le sehlopha sa benzyl se kopantsoeng le sehlopha se sebetsang sa carbamate ka karolo ea piperidine. E 'ngoe ea litšebeliso tsa mantlha tsa Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ke selelekela. kapa tse lipakeng tsa motsoako oa metsoako e fapaneng ea meriana.Ho ba teng ha selikalikoe sa piperidine ho fana ka motsoako ona ka mekhoa e mengata ea lik'hemik'hale tsa lik'hemik'hale, e leng se etsang hore e be ntho ea bohlokoa ea ho qala ho kopanya limolek'hule tse rarahaneng tse fapaneng.Ka ho hlahisa motsoako ona ka tsela ea maiketsetso, litsebi tsa lik'hemik'hale li ka fumana mefuta e mengata ea metsoako e mecha e nang le mekhoa ea phekolo e ka 'nang ea e-ba teng. moaho bakeng sa nts'etsopele ea meriana e mecha e shebaneng le litsela tse itseng tsa likokoana-hloko kapa li-receptors.Likarolo tsa eona tsa sebopeho li etsa hore e be e loketseng ho kenyelletsoa ka har'a limolek'hule tsa lithethefatsi, e sebetsang e le pharmacophore kapa sehlopha sa bohlokoa se sebetsang se ikarabellang bakeng sa mosebetsi o lakatsehang.Ka ho fetola likarolo tsa benzyl, piperidine, kapa carbamate, bafuputsi ba ka ntlafatsa matla a lithethefatsi, khetho, le thepa ea pharmacokinetic.Motsoako o ka boela oa sebetsa e le sesebelisoa kapa motsoako oa litšupiso bakeng sa ho sibolloa ha lithethefatsi le lithuto tsa kamano ea sebopeho (SAR).Ka ho bapisa ts'ebetso ea tlhaho ea lintho tse fapaneng tse nkiloeng kapa li-analogues tsa Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride, bafuputsi ba ka fumana leseli mabapi le kamano ea ts'ebetso ea sebopeho, e ba lumellang ho etsa moralo o matla haholoanyane. le metsoako e khethang.Tlhahisoleseding ena ke ea bohlokoa bakeng sa ho ntlafatsa metsoako ea loto le nts'etsopele ea batho ba atlehang ho sebelisa lithethefatsi. Ho feta moo, Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride e ka sebelisoa lipatlisisong tsa lik'hemik'hale tsa meriana. ho ithuta mokhoa oa ts'ebetso ea lithethefatsi tse itseng kapa ho batlisisa metabolism ea lithethefatsi.Ka ts'ebeliso ea liphetolelo tse ngotsoeng ka radiolabele kapa tse tšoailoeng tsa motsoako ona, bafuputsi ba ka lekola kabo ea eona le metabolism lits'ebetsong tsa baeloji.Boitsebiso bona bo thusa ho utloisisa kamoo lithethefatsi li sebetsoang le ho ntšoa kateng 'meleng, ho fana ka lintlha tsa bohlokoa mabapi le tšebelisano ea lithethefatsi, litekanyetso tsa litekanyetso, le litšebelisano tse ka bang teng tsa lithethefatsi le lithethefatsi.Ka kakaretso, Benzyl N-[2-(piperidin-4-yl) propan- 2-yl]carbamate hydrochloride ke motsoako o feto-fetohang o sebelisoang haholo lipatlisisong tsa meriana le nts'etsopele ea lithethefatsi.Likarolo tsa eona tsa sebopeho li etsa hore e be ea bohlokoa e le selelekela sa motsoako oa metsoako e fapa-fapaneng ea meriana le e le motheo oa ho haha ​​​​litlhare tse ncha.Ho feta moo, e sebetsa e le sesebelisoa sa lithuto tsa SAR, ho sibolloa ha lithethefatsi, le lipatlisiso tsa metabolism.Lisebelisoa tse fapaneng tsa Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride e totobatsa bohlokoa ba eona ho nts'etsopele ea lisebelisoa tse ncha tsa phekolo le tsoelo-pele ea lik'hemik'hale tsa meriana.