Lihlahisoa

Lihlopha tse tharo tsa banna ba baholo ba litšoene tsa cynomolgus (Macaca fascicularis) li ne li pepesehetse 200 micrograms / m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], 200 micrograms (NH4) 2PtCl6 ka nako e le 'ngoe le 1 ppm ozone (O3), kapa ho O3 1 feela.Liphoofolo li ne li pepesoa ka ho hema lihora tse 6 ka letsatsi, matsatsi a 5 ka beke bakeng sa libeke tse 12.Moralo oa liteko o ne o kenyelletsa tlhahlobo ea methacholine preexposure le Na2PtCl6 bronchoprovocation challenge, Na2PtCl6 threshold skin test, le sera bakeng sa litlhahlobo tsa li-antibodies.Libeke tse peli kamora ho pepeseha ha 12-wk, li-indices tsona tsena li ile tsa hlahlojoa bocha.Mosebetsi oa motheo oa pulmonary ha oa ka oa ameha haholo ke mekhoa ea ho pepeseha;leha ho le joalo, motsoako oa ho pepeseha ho O3 le (NH4) 2PtCl6 o fokolitse haholo motsoako oa letsoai la platinum (Pt) le methacholine e hlokahalang ho eketsa karolelano ea ho hanyetsa phallo ea matšoafo (RL) 200% (EC200 RL).Ho pepesetsoa Ozone kapa Pt feela ha hoa ka ha e-ba le phello e kholo ho liparamente tsena.Litekanyetso tsa Platinum le methacholine EC200 RL li ne li amana haholo bakeng sa lihlopha tse peli tse pepesitsoeng ke Pt ka mor'a ho pepeseha.Lintlha tsena li bontšitse hore ho pepeseha ha O3 le Pt ho eketsehile haholo (Pt) le nonspecific (methacholine) bronchial hyperreactivity hangata ho feta ho pepesehela O3 kapa Pt letsoai feela.Ho pepeseha ha O3 hammoho le Pt ho boetse ho eketsa haholo liketsahalo tsa liteko tse ntle tsa letlalo la Pt ha li bapisoa le lihlopha tse ling tsa ho pepeseha.Ho ts'oana le boiphihlelo ba motho, tlhahlobo ea radioallergosorbent (RAST) bakeng sa li-antibodies tse khethehileng tsa Pt e ne e se bonolo joalo ka tlhahlobo ea letlalo e tobileng ho hlwaya batho ba kulang.