Albendazole Cas: 54965-21-8
| Nomoro ea lethathamo | XD91873 |
| Lebitso la Sehlahiswa | Albendazole |
| CAS | 54965-21-8 |
| Foromo ea molek'hulela | Setšoantšo sa C12H15N3O2S |
| Boima ba Molek'hule | 265.33 |
| Lintlha tsa polokelo | 2-8°C |
| Khoutu ea Lekhetho e Kopantsoeng | 29332990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu ea kristale |
| Assay | 99% mets |
| Sebaka se qhibilihang | 208-210 °C |
| tekano | 1.2561 (khakanyo e fosahetseng) |
| index ea refractive | 1.6740 (khakanyo) |
| ho qhibiliha | Ha e qhibilihe ka metsing, e qhibiliha ka bolokolohi ka anhydrous formic acid, e qhibiliha hanyenyane haholo ka methylene chloride, hoo e batlang e sa qhibilihe ka har'a ethanol (96 lekholong). |
| pka | 10.72±0.10(E boletsoeng esale pele) |
| Ho qhibiliha ha Metsi | 0.75mg/L(209 ºC) |
Albendazole ke moriana o sebelisetsoang ho phekola mafu a bakoang ke likokoana-hloko.E ka fuoa ho phekola tšoaetso e sa tloaelehang ea boko (neurocysticercosis) kapa e ka fuoa ho phekola tšoaetso ea likokoana-hloko e bakang letšollo la bohlokoa (microsporidiosis).
E tsoang ho benzimidazole, albendazole ke sethethefatsi se nang le antihelmintic spectrum.E bonts'a phello ea antihelmintic khahlanong le li-cestodes le li-nematodes tse hlokolosi ka ho thibela ts'ebetso ea ho kenngoa ha tsoekere ke likokoana-hloko, e hlahisoang ka ho fokotseha ha mehloli ea glycogen le ho fokotseha ha boemo ba adenosintriphophate.Ka lebaka leo, kokoana-hloko ena e khaotsa ho tsamaea ebe e shoa.E sebelisoa bakeng sa tšoaetso ea Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, le Trichuris trichiura.Li-synonyms tsa sethethefatsi sena ke SKF 62979 le tse ling.
Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) ke anthelmintic e pharalletseng e sa rekisoeng ha joale Amerika Leboea.E fumaneha ho tsoa ho moetsi molemong oa tšebeliso e nang le kutloelo-bohloko.Albendazole e sebelisoa haholo lefatšeng ka bophara bakeng sa phekolo ea tšoaetso ea intestinalnematode.E sebetsa hantle joalo ka kalafo ea lethal le le leng bakeng sa ascariasis, tšoaetso ea hookworm ea Lefatše le Lecha le la Khale, le trichuriasis.Phekolo ea litekanyetso tse ngata ka albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, le lefu la hydatid.Katleho ea albendazole khahlano le liboko tsa tapeworms (cestodes) hangata e fetoha ebile ha e khahlise haholo.
Albendazole e hlaha e le phofo e tšoeu ea kristale e batlang e sa qhibilihe ka metsing.Ho monya ha albendazole ka molomo ho matlafatsoa ke lijo tse mafura.Setlhare se kenella ka potlako le ka mokhoa o pharalletseng oa metabolism ho sulfoxide, e leng mofuta o sebetsang oa plasma.Ho felisoa ha halofo ea bophelo ba sulfoxide ho tloha lihora tse 10 ho isa ho tse 15.Ho na le biliary excretion le enterohepatic recycling ea albendazolesulfoxide e etsahala.Albendazole hangata e mamelloa hantle kalafong ea lethal dose e le 'ngoe bakeng sa li-nematode tsa mala.Theko e phahameng, phekolo ea nako e telele e hlokahalang bakeng sa phekolo ea lefu la clonorchiasis orechinococcal e ka fella ka liphello tse bohloko tse kang ho tepella maikutlong ha masapo, ho phahama ha li-enzyme tsa sebete le alopecia.
Albendazole e na le tšebetso e pharaletseng khahlanong le nematodes le cestodes ea mala, hammoho le li-flukes tsa sebete Opisthorchis sinensis, Opisthorchis viverrini, le Clonorchis sinensis.E boetse e sebelisitsoe ka katleho khahlanong le Giardia lamblia.Albendazole ke phekolo e sebetsang ea hydatid cyst disease (echinococcosis), haholo-holo ha e tsamaea le praziquantel.E boetse e sebetsa hantle ho alafang cerebral le spinal neurocysticercosis, haholo-holo ha e fanoa ka dexamethasone.Albendazole e buelloa bakeng sa phekolo ea gnathostomiasis.
